Publications by authors named "Haopeng Li"

Biopolymer-based complex coacervates hold promising prospects in the field of biomedicine. However, their low stability in environments with extreme pH and high salt concentrations, largely due to weakly charged biomacromolecules and insufficient understanding of their assembly processes, has hindered their practical applications in oral drug delivery. Here, we have developed Dopa-containing peptide-based complex coacervates that are stable across a wide range of pH (1-11) and salt concentrations.

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Exosomal microRNAs produced from mesenchymal stem cells (MSCs) are crucial in the management of acute lung injury (ALI). In this work, mMSCs separated from bone marrow were used to extract exosomes (MSC-Exos). MSC-Exos treatment attenuated pathological changes and scores, and edema in ALI mice.

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Background: Currently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).

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Background: Dural arteriovenous fistulas (DAVFs) pose a significant health threat owing to their high misdiagnosis rate. Case reports suggest that DAVFs or related acute events may follow medication use; however, drug-related risk factors remain unclear. In clinical practice, the concomitant use of multiple drugs for therapy is known as "polypharmacy situations," further increasing the risk of drug-induced DAVF.

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The impact of antioxidant intake on the prognosis of osteoarthritis (OA) patients remains unclear. The aim of this study was to investigate the relationship between the composite dietary antioxidant index (CDAI) and all-cause mortality in OA patients. A total of 35,590 participants with OA from the National Health and Nutrition Examination Survey (1999-2020) were included in this study.

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Purpose: This study aims to evaluate the predictive value of the renal resistive index (RRI) and β2-microglobulin (β2-MG) for acute kidney injury (AKI) in urosepsis patients and to develop a clinical prediction model for AKI risk.

Methods: Data from 108 urosepsis patients at Tongji Hospital were analyzed. Patients were divided into AKI (67 patients) and non-AKI (41 patients) groups based on KDIGO guidelines.

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Objective: Long non-coding RNAs (lncRNAs) play an important role in tumor progression. Numerous studies show that lncRNAs are strongly associated with prostate cancer (PCa) progression. The aim of this study was to investigate the pathway through which lncRNA regulates PCa progression by bioinformatics analysis and experiments.

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Intravenous immunoglobulin (IVIG) is frequently administered to patients with severe fever with thrombocytopenia syndrome (SFTS), particularly those with severe manifestations, although its efficacy remains controversial. The study retrospectively analyzed the effects of IVIG administration on SFTS patients in both mild and severe groups. The primary outcome measure was 28-day mortality.

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Article Synopsis
  • - The high cost of vanadium electrolytes in vanadium flow batteries (VFBs) is largely due to slow chemical reactions; understanding these reactions through density functional theory can help improve them.
  • - Using catalytic site engineering, researchers designed iron single-atoms embedded in nitrogen-doped carbon nanotubes to enhance reaction speeds and decrease energy consumption when using vanadium electrolytes.
  • - The new method showed significantly improved reaction rates, reducing energy costs by 22.5%, while also producing high-quality vanadium electrolytes with minimal impurities.
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Prostate cancer is a significant contributor to cancer-related mortality, and the tumor typically develops into castration-resistant prostate cancer (CRPC). Hence, few effective clinical strategies are available to patients with advanced disease. Extrachromosomal circular DNA (eccDNA) is a type of circular DNA originating from the chromosomes but is likely independent of them.

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  • Severe fever with thrombocytopenia syndrome (SFTS) is a dangerous infectious disease, and early detection of patients is vital for effective treatment.
  • A study used LASSO-Cox regression to identify key risk factors for patients progressing to critical illness, leading to a nomogram with factors like viral loads and liver enzyme levels.
  • The nomogram showed strong predictive accuracy (AUCs of 0.802 for 7 days and 0.859 for 14 days), helping to stratify patients into different risk categories and visually represented using a heat map.
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  • Severe fever with thrombocytopenia syndrome (SFTS) is a dangerous infectious disease caused by the SFTS virus, prompting the need for early identification of high-risk patients through a dynamic model.
  • The study analyzed data from 299 SFTS patients using LASSO logistic regression to determine six key factors that predict disease progression and mortality, including age and specific clinical symptoms.
  • The developed dynamic nomogram effectively predicts the severity of SFTS at admission and helps estimate 28-day mortality, with its performance validated through various statistical measures and available for use online.
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This study aims to investigate the effect of adipose-derived stem cells (ADSCs) transplantation on progranulin (PGRN) expression and functional recovery in rats with spinal cord injury (SCI). ADSCs were isolated from the inguinal adipose tissue of rats. A SCI model was created, and ADSCs were injected into the injured area.

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Natural evolution endows some insects and marine organisms with a special class of protein-based elastic tissues that possess energy feedback characteristics, providing them with the foundation for jumping and flying, and protecting them from the damage caused by movements or waves. However, the design and fabrication of such protein-based elastomeric materials that can function in human society through biomimetic strategies still remains challenging. Recombinant proteins designed by synthetic biology can mimic the advantageous structures in natural proteins and can be biosynthesized without the requirements for harsh conditions such as high temperatures and cytotoxic agents, which provides a great opportunity to prepare protein-based elastomeric materials.

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Article Synopsis
  • Neurological disorders like Parkinson's disease and strokes can be really serious and affect how people live and function.
  • Brain-Computer Interface (BCI) technology helps people communicate directly with devices using their brains, which shows a lot of promise for helping with these disorders.
  • The review looks at the latest BCI research and its possible future use in treating different neurological problems, while also discussing the need for better studies, ethical considerations, and teamwork between experts.
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Red fluorescent hydrogels possessing injectable and self-healing properties have widespread potential in biomedical field. It is still a challenge to achieve a biomacromolecules based dynamic hydrogels simultaneously combining with excellent red fluorescence, good mechanical properties, and biocompatibility. Here we first explore hydrophilic inclusion complex of (R-CDs@α-CD) derived from hydrophobic red fluorescent carbon dots (R-CDs) and α-cyclodextrin (α-CD), and then achieved a red fluorescent and dynamic polysaccharide R-CDs@α-CD/CEC-l-OSA hydrogel.

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Castration-resistant prostate cancer (CRPC) represents the final stage of prostate cancer (PCa). Cabazitaxel, a taxane chemotherapy drug, is used in treating CRPC. However, patients with CRPC eventually develop resistance to cabazitaxel, and the underlying mechanism remains unclear.

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Background And Purpose: Hemorrhagic transformation remains a potentially devastating complication of acute ischemic stroke. We aimed to evaluate whether the hypoperfusion intensity ratio, a parameter derived from CT perfusion imaging, is associated with the development of hemorrhagic transformation in patients with anterior large-artery occlusion who had undergone thrombectomy.

Materials And Methods: We retrospectively reviewed data from patients with consecutive acute ischemic strokes who had achieved successful recanalization (Thrombolysis in Cerebral Infarction score ≥2b) between January 2020 and December 2023.

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Biological systems can create materials with intricate structures and specialized functions. In comparison, precise control of structures in human-made materials has been challenging. Here we report on insect cuticle peptides that spontaneously form nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from the mixing of water and acetone drives the localization and self-assembly of the peptides into hollow nanocapsules.

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Permeability is a key factor affecting efficient gas drainage from coal seams, and acidification and vibration shock are effective means to increase permeability in original low-permeability coal seams. To study the gas desorption characteristics of coking coal under the coupling effect of mining disturbance and acidification permeability enhancement, taking the coal seam of Shoushan No. 1 coal as the research object, a self-built adsorption-desorption vibration test platform was used.

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Background: Sepsis-associated acute kidney injury (SA-AKI) is a common complication in patients with sepsis, triggering high morbidity and mortality. Maresin-1 (MaR1) is a pro-resolution lipid mediator that promotes the resolution of acute inflammation and protects organs from inflammation.

Methods: In this study, we established an SA-AKI model using cecal ligation and puncture (CLP) and investigated the effect and mechanism of MaR1.

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Background: Studies have proved that low albumin level is associated with increased mortality in most diseases, such as chronic kidney disease and hepatic cirrhosis. However, the relationship between albumin and all-cause death in heart failure patients in China is still unclear.

Objectives: We aimed to investigate the association between albumin level and 28-day mortality in Chinese hospitalized patients with NYHA IV heart failure.

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Biomacromolecules based injectable and self-healing hydrogels possessing high mechanical properties have widespread potential in biomedical field. However, dynamic features are usually inversely proportional to toughness. It is challenging to simultaneously endow these properties to the dynamic hydrogels.

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Introduction: To explore the effect of CRRT using CVVHDF + HP on the removal of inflammatory mediators in patients with septic shock complicated with AKI.

Methods: A total of 20 patients between January 1, 2018, and December 31, 2021, were included. The patients were randomly divided into the treatment group (CVVHDF + HP) and the control group (CVVHDF).

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Synopsis of recent research by authors named "Haopeng Li"

  • - Haopeng Li's recent research focuses on critical health conditions, including severe fever with thrombocytopenia syndrome (SFTS) and prostate cancer, investigating both treatment efficacies and predictive models to enhance patient outcomes.
  • - His studies explored novel therapeutic approaches, such as intravenous immunoglobulin for SFTS and adipose-derived stem cell transplantation for spinal cord injury, highlighting their potential benefits in patient recovery and disease progression.
  • - Additionally, Li's work extends into materials science and technology, including the development of dynamic hydrogels and engineered protein elastomeric materials, aiming to bridge the gap between biological functions and medical applications.

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