Publications by authors named "Haoning Xiong"
Intervertebral disc degeneration (IVDD) is intricately associated with various forms of programmed cell death (PCD). Identifying key PCD types and associated genes is essential for understanding the molecular mechanisms underlying IVDD and discovering potential therapeutic targets. This study aimed to elucidate core PCD types, related genes, and potential drug interactions in IVDD using comprehensive bioinformatic and experimental approaches.
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- * Researchers created a new drug by combining idebenone (an antioxidant) with paclitaxel (a microtubule-stabilizing agent) using a special linker, allowing it to be retained in the spinal cord for at least two weeks.
- * This new formulation showed improved motor function and axon regeneration in mice with SCI, while also reducing harmful processes in nerve cells, suggesting it could be an effective treatment strategy for SCI.
Arachidonic acid (AA) plays a critical role in inflammatory regulation and secondary injury after spinal cord injury (SCI). However, the overall AA metabolism profile in the acute phase of SCI remains elusive. Here we quantified AA metabolomics by High Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Method (LC-MS/MS) using spinal cord tissue collected at 4 h, 24 h and 48 h after contusive SCI in rats.
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