Development of a proton CT imaging system using scintillator-based range detection.

Background: The accuracy of proton therapy and preclinical proton irradiation experiments is susceptible to proton range uncertainties, which partly stem from the inaccurate conversion between CT numbers and relative stopping power (RSP). Proton computed tomography (PCT) can reduce these uncertainties by directly acquiring RSP maps.

Purpose: This study aims to develop a novel PCT imaging system based on scintillator-based proton range detection for accurate RSP reconstruction.