Identification of c.146G > A mutation in a Fabry patient and its correction by customized Cas9 base editors in vitro.

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the GLA gene, leading to reduced α-galactosidase (α-Gal A) activity. Current treatments, like enzyme replacement, have limitations affecting efficacy and patient outcomes. CRISPR/Cas9 genome editing tools may offer the potential to develop therapeutic strategy via correcting GLA mutations.

High-precision and wide-wavelength range FBG demodulation method based on spectrum correction and data fusion.

Optical fiber sensing technology plays an important role in the application of the sensing layer of the Internet of Things. The core of this technology is the demodulation of the fiber Bragg grating (FBG) sensing system. Since the FBG sensor utilizes the wavelength change to respond to the measured size, it is of great significance to improve the accuracy of the FBG wavelength demodulation.