Snapshot computational spectroscopy enabled by deep learning.

Spectroscopy is a technique that analyzes the interaction between matter and light as a function of wavelength. It is the most convenient method for obtaining qualitative and quantitative information about an unknown sample with reasonable accuracy. However, traditional spectroscopy is reliant on bulky and expensive spectrometers, while emerging applications of portable, low-cost and lightweight sensing and imaging necessitate the development of miniaturized spectrometers.

Emergence of silent NDM-1 carbapenemase gene in carbapenem-susceptible Klebsiella pneumoniae: Clinical implications and epidemiological insights.

The global dissemination of carbapenemase genes, particularly bla, poses a significant threat to public health. While research has mainly focused on strains with phenotypic resistance, the impact of silent resistance genes has been largely overlooked. This study documents the first instance of silent bla in a cluster of clonally related carbapenem-susceptible K.

Multiplex-genome-editing based rapid directional improvement of complex traits in rice.

Although thousands of genes have been identified or cloned in rice (Oryza sativa) in the last two decades, the majority of them have only been separately characterized in specific varieties or single-gene modified backgrounds, thus limiting their practical application. We developed an optimized multiplex genome editing (MGE) toolbox that can efficiently assemble and stably express up to twelve sgRNA targets in a single plant expression vector. In this study, we established the MGE-based Rapid Directional Improvement (MRDI) strategy for directional improvement of complex agronomic traits in one small-scale rice transformation.

Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation.

Background: Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, provide potential biomarkers for the diagnosis and treatment of CHD. However, the mechanisms underlying miRNAs-mediated regulation of cardiac development and CHD malformation remain to be further elucidated.

Outer membrane vesicles mediating horizontal transfer of the epidemic carbapenemase gene among .

OXA-232 is one of the most common OXA-48-like carbapenemase derivatives and is widely disseminated in nosocomial settings across countries. The gene is located on a 6-kb non-conjugative ColKP3-type plasmid, while the dissemination of into different species and the polyclonal dissemination of OXA-232-producing revealed the horizontal transfer of . However, it's still unclear how this non-conjugative ColKP3 plasmid could facilitate the mobilization of .

Teacher-Assessed Linguistic and Social Abilities in Chinese Children's Reading Acquisition: A Longitudinal Study.

The study explored the relationship between teacher assessments of students' general language-cognitive and social-emotional abilities and Chinese children's reading development over an academic year. A series of reading measures (including reading vocabulary, reading comprehension, and lexical inferencing ability) were administered to Chinese-speaking second graders ( = 123) across time. Meanwhile, their six head teachers and assistant head teachers were asked to complete assessments of their language-cognitive and social-emotional abilities prior to the first data collection.

The mechanism of the Shuang Bai Su Qing recipe in treating periodontitis based on network pharmacology and molecular docking technology.

Aim: To explore the material basis of action of the Shuang Bai Su Qing recipe in the treatment of periodontitis using network pharmacology.

Methods: Using TCMSP, we screened the chemical components of 5 drugs. The components were input into the UniProt and PubChem databases to obtain target proteins; Genecards, Online Mendelian Inheritance in Man (OMIM), and CEO databases were used to screen target proteins for periodontal disease.

Transforming Hetera-Buckybowls into Chiral Conjugated Polycycles Incorporating Epoxycyclooctadiene: a Two-Step Approach.

Chiral π-conjugated polycycles have garnered increasing attention due to versatile applications in optoelectronic materials and biological sciences. In this study, we report the synthesis of chiral π-conjugated polycycles incorporating a chiral epoxycyclooctadiene moiety. Our synthetic strategy capitalizes on the novel reactions of hetera-buckybowl triselenasumanene (TSS) and is achieved in two-step manner.

Colonization of extended-spectrum β-lactamase-producing Enterobacteriaceae does not affect subsequent infection and liver transplant outcomes: a retrospective observational cohort study.

Objective: To investigate the colonization rate of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), subsequent infections by ESBL-E and ESBL-producing gram-negative bacilli (ESBL-GNB), and the effect of ESBL-E colonization on clinical outcomes in liver transplantation (LT) recipients.

Methods: This is a retrospective cohort study that included patients who underwent LT at Shanghai Renji Hospital between July 2016 and December 2017. Rectal swabs from LT patients at the postoperative ICU enrollment were screened anonymously for ESBL-E carriage.

Examining the dimensionality of morphological knowledge and morphological awareness and their effects on second language vocabulary knowledge.

Morphological knowledge and morphological awareness are multidimensional and both have been confirmed to make important contributions to vocabulary knowledge. However, the extant literature has not made a clear demarcation between morphological knowledge and morphological awareness. The current study examined the underlying components of morphological knowledge and morphological awareness as well as their effects on vocabulary knowledge.

Xiaoyin Jiedu Granules may alleviate psoriasis-like skin diseases in mice by regulating sphingosine 1-phosphate receptor expression and reducing Th17 cells.

Sphingosine-1-phosphate (S1P) is associated with the onset and severity of psoriasis, a chronic inflammatory skin disease linked to innate and adaptive immune responses. This study explores the therapeutic effect of Xiaoyin Jiedu Granules, a combination of traditional Chinese medicines, on psoriasis-like skin lesions in mice and the underlying mechanism. We used imiquimod (IMQ) to induce psoriasis-like dermatitis in mice; the effects of Xiaoyin Jiedu Granules on S1P receptors (S1PRs) were investigated using histology and immunohistochemistry.

How phonological and orthographic decoding complicates the simple view of reading in Chinese: examining mediation through listening comprehension.

Advocates of the science of reading have invoked the simple view of reading (SVR) to justify an approach that foregrounds decoding in early reading instruction. SVR describes reading comprehension as the product of decoding and listening comprehension. The current study examined the complexity of the SVR, focusing on the phonological and orthographic decoding in third-grade readers of Chinese.

Performance of Two Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Systems for Identification of the Viridans Group Streptococci.

Background: Due to similar colony morphology among viridans group streptococci (VGS), the differentiation of VGS species remains difficult in routine clinical microbiology. Recently, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) has been described as a fast method for identifying various bacteria at species level, and also for the VGS strains.

Methods: A total of 277 VGS isolates were identified with the two MALDI-TOF MS systems (VITEK MS and Bruker Biotyper).

IPA1 improves drought tolerance by activating SNAC1 in rice.

Drought is a major abiotic stress to rice (Oryza sativa) during growth. Ideal Plant Architecture (IPA1), the first cloned gene controlling the ideal plant type in rice, has been reported to function in both ideal rice plant architecture and biotic resistance. Here, we report that the IPA1/OsSPL14, encoding a transcriptional factor, positively regulates drought tolerance in rice.

Non-selective language activation in L2 lexical inference and text comprehension: Comparing skilled and less-skilled readers.

Non-selective language activation refers to the automatic co-activation of L1 and L2 information. In L2 reading, the activated L1 information can be utilized to different degrees to facilitate lexical inference and text comprehension. The current study examined the contributions of L1-L2 translation and lexical inference to text comprehension.

Prosodic Transfer in English Literacy Skills among Chinese Elementary-Age Students: Controlling for Non-Verbal Intelligence.

Building upon the prosodic transfer hypothesis, the current study aims to examine the intermediary effect of English stress on the relation between Chinese lexical tone awareness and English word-level literacy (reading and spelling) as well as the moderating effect of English oral vocabulary proficiency on the cross-linguistic association. Grade 4 Chinese learners of English ( = 224) participated in this study and were assessed for their tone and stress sensitivity, English oral vocabulary, English word reading, and English word spelling. Mediated multivariate analyses with moderation were used to explore: (1) whether the influence of lexical tone perception on L2 word reading and spelling was mediated by English stress as posited in the prosodic transfer hypothesis; (2) whether the effects of tone on English word reading and spelling performance varied as a function of oral vocabulary levels.

The dimensionality of morphological awareness in reading comprehension among Chinese early adolescent readers.

Recent research has included multiple measures of morphological awareness to address the dimensionality of morphological construct in the context of modeling skilled reading. However, a majority of studies have an Anglocentric focus. The current study aims to extend the previous studies to logographic learners by evaluating the dimensionality of morphological awareness in higher-order reading comprehension among Chinese adolescent readers.

Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study.

Background: The therapeutic effects of a combination of Chinese medicines called Biyu decoction have been clinically verified, although its molecular targets in psoriasis remain unknown.

Aim: To explore the molecular mechanisms of Biyu decoction for psoriasis treatment.

Methods: In this network pharmacology and molecular docking study, the Traditional Chinese Medicine Systems Pharmacology database was searched for Biyu decoction active ingredients.

[Screening of Differential Expression Autophagy Genes Related to the Prognosis of Diffuse Large B-Cell Lymphoma and Establishment of an Autophagy Model].

Objective: To screen the differential expression of diffuse large B-cell lymphoma (DLBCL) autophagy-related gene (ARG), explore the mechanism of differential expression of autophagy gene (DEARG) in the occurrence and development of DLBCL and establish a prognostic model.

Methods: Using the NCICCR database containing clinical information and gene expression profile data of 481 patients with DLBCL and the HADb database containing 232 ARGs, the differential expression of ARG in DLBCL was determined by R language, the relationship between ARG and the occurrence and development of DLBCL was analyzed by GO and KEGG, the polygene prognostic model was established by Cox regression algorithm, the survival curve was drawn by Kaplan-Meier method, and the reliability of the prognostic model was evaluated by ROC curve.

Results: A total of 122 DEARGs were extracted from lymph node samples of 481 patients with DLBCL and 5 normal lymph nodes, including 4 up-regulated genes and 118 down-regulated genes.

Phenol-soluble modulin contributes to the dispersal of isolates from catheters.

Staphylococcus epidermidis (), a human commensal, has been implicated in invasive infection in humans due to their ability to form biofilm. It is assumed that when a biofilm is dispersed it will subsequently cause a more severe infection. The clinical significance of isolated from sterile body fluid (BF) remains unclear, and might be related to dispersal from catheter-associated biofilm infection.

Game modelling and stability strategy research on distributed leadership pattern: A tripartite evolutionary game perspective.

Distributed leadership pattern has been a topic of growing interest in recent years, recognizing that much remains to be known about this phenomenon. The research on distributed leadership acknowledges that responsibility and power are not exclusively limited to one formal leader, but are distributed between formal and informal leaders. The decision-making behavior of team members plays a vital role in optimizing cooperation and team performance.

Word Knowledge in L2 Chinese Lexical Inference: A Moderated Path Analysis of Language Proficiency Level and Heritage Status.

This study explored the effect of word knowledge facets (word-general and word-specific knowledge) on second language (L2) Chinese lexical inference by highlighting the moderating effect of language proficiency level and learners' heritage status. L2 Chinese learners with a mixture of linguistic (low-intermediate and high-intermediate) and cultural (heritage and non-heritage) backgrounds completed a series of word-knowledge measurements as well as a lexical inferencing task. Through a moderated path model, the study demonstrated that word-general knowledge (morphological awareness) and word-specific knowledge (vocabulary knowledge) contributed to L2 Chinese lexical inference.

Concurrent and longitudinal contributions of phonological awareness to early adolescent Chinese reading acquisition.

This study investigated universal and language-specific phonological awareness in reading development among Chinese early adolescent students. Seventy-six children participated in this study and completed a series of reading tasks at two data collection points across Grades 5 and 6. In Grade 5, universal phonological awareness (syllable, onset, rhyme, and phoneme awareness), language-specific phonological awareness (tone awareness) as well as character recognition and production measurements were administered to the participants.

Effect of mutations on tumor mutation burden and its potential prognostic significance for cutaneous melanoma.

Objectives: , a mucin marker with a high mutation probability, is closely related to the occurrence, development, response to treatment, and prognosis of melanoma. As melanoma has high immunogenicity, immunotherapy has become a routine treatment. Tumor mutation burden (TMB) is the most common indicator for determining appropriate immunotherapy.

Word Knowledge Dimensions in L2 Lexical Inference: Testing Vocabulary Knowledge and Partial Word Knowledge.

This study explored the role of word knowledge dimensions in second language (L2) word-meaning inference. College-level L2 learners (N = 121) participated in this study and completed a series of word knowledge tests including vocabulary size, word associates, morpheme-form knowledge, morpheme-meaning knowledge, morpheme discrimination, and morpheme recognition. Two modules of lexical inferencing tasks (pseudoword inference and real-word inference) were also administered to the participants.