Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.

Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely limited. Here, we develop a DNAzyme-based method to detect DNA adduct damage for toxicity assessment of drugs and chemicals.

Simultaneous detection of acetaminophen, catechol and hydroquinone using a graphene-assisted electrochemical sensor.

Simple, rapid and sensitive analysis of drug-derived pollutants is critically valuable for environmental monitoring. Here, taking acetaminophen, hydroquinone and catechol as a study example, a sensor based on an ITO/APTES/r-GO@Au electrode was developed for separate and simultaneous determination of phenolic pollutants. ITO electrodes that are modified with 3-aminopropyltriethoxysilane (APTES), graphene (GO) and Au nanoparticles (Au NPs) can significantly enhance the electronic transport of phenolic pollutants at the electrode surface.

Simple, rapid, and visual electrochemiluminescence sensor for on-site catechol analysis.

Environmental pollution caused by aromatic compounds such as catechol (Cat) has become a major issue for human health. However, there is no simple, rapid, and low-cost method for on-site monitoring of Cat. Here, based on ECL quenching mechanism, we develop a simple, rapid and visual mesoporous silica (MSNs)-electrochemiluminescence (ECL) sensor for on-site monitoring of Cat.

Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids.

Pyrrolizidine alkaloids (PAs) and PA N-oxides are hepatotoxic natural products, produced by over 6000 plant species worldwide. However, an unmet need remains for confirmative measurement of PAs in routine clinical tests. Here, we develop a visual, easy-to-use, and economic mesoporous silica-electrochemiluminescence (MPS-ECL) sensor for point-of-care (POC) testing of PAs, utilizing MPS's amplification effect on positive ions.

Electrogenerated chemiluminescence of a Ru(bpy) /arginine system: a specific and sensitive detection of acetaminophen.

Ru(bpy)Cl/TPrA is a prominent and widely used ECL system in analytical science. However, the co-reactant TPrA restricts the variety of applications because of its toxicity, volatility, and high cost. Here, we use arginine (Arg) as an alternative co-reactant for Ru(bpy) by taking advantage of its low cost, non-toxicity, and biocompatibility.

Mesoporous silica-mediated controllable electrochemiluminescence quenching for immunosensor with simplicity, sensitivity and tunable detection range.

Straightforward and accurate measurement of medical biomarkers is of essential importance in clinical diagnostics and treatments. However, the major challenge is the diversity in dynamic range of different biomarkers ranging from pg mL to μg mL in various body fluids and tissues among patients. Here, we develop a mesoporous silica (MS)-mediated controllable electrochemiluminescence (ECL) quenching of immunosensor that allows accurate immunoassays with simplicity, sensitivity and tunable sensing range.

Comparison Study on the Estimation of the Spatial Distribution of Regional Soil Metal(loid)s Pollution Based on Kriging Interpolation and BP Neural Network.

Soil pollution by metal(loid)s resulting from rapid economic development is a major concern. Accurately estimating the spatial distribution of soil metal(loid) pollution has great significance in preventing and controlling soil pollution. In this study, 126 topsoil samples were collected in Kunshan City and the geo-accumulation index was selected as a pollution index.