piRNAs and circRNAs acting as diagnostic biomarkers in clear cell renal cell carcinoma.

The discovery of diverse functions and mechanisms in cancer has underscored the significance of emerging non-coding RNAs (ncRNAs), such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs), within the clinical context of cancer. Understanding their role in clear cell renal cell carcinoma (ccRCC) is imperative and necessitates comprehensive investigation. This study aims to further explore the diagnostic potential of piRNAs and circRNAs for ccRCC.

Anlotinib may have a therapeutic effect on papillary craniopharyngiomas without the BRAFv600e mutation.

Background: Although successful treatment of papillary craniopharyngiomas (PCPs) with BRAFv600e inhibitors has been reported in clinical trials, studies have shown that approximately 10% of PCPs lack the BRAFv600e mutation and that BRAFv600e inhibitors may not be significantly effective against these tumors. However, no studies have focused specifically on BRAFv600e PCPs.

Methods: Spatial transcriptome sequencing was performed on calcified PCP tissue to identify novel subtypes of PCP cells.

Strain analysis of intra- and extra-medullary implants for fixing the subtrochanteric femoral fractures.

Background: Intra or extra medullary fixation for subtrochanteric fractures (STF) is still controversial. And the strain on fracture site and implant have not been reported. The aim of our study is to evaluate the differences in strain at the medial and lateral cortex of the subtrochanteric region with PFNA, 'upside-down' LISS and PFLP fixing different types of subtrochanteric femoral fractures under static loads.

Assessing severe pneumonia risk in children via clinical prognostic model based on laboratory markers.

Pneumonia represents a significant cause of mortality in children globally, emphasizing the importance of identifying high-risk patients to improve clinical outcomes. There is a lack of reliable laboratory markers and robust risk stratification models for clinical decision support in pediatric pneumonia. This study extracted data from the Paediatric Intensive Care database for 749 children under 3 years with severe pneumonia.

The role of the components of PM in the incidence of Alzheimer's disease and related disorders.

Background: The associations of PM mass and various adverse health outcomes have been widely investigated. However, fewer studies focused on the potential health impacts of PM components, especially for dementia and Alzheimer's diseases (AD).

Methods: We constructed a nationwide population-based open cohort study among Medicare beneficiaries aged 65 or older during 2000-2018.

Research on the local path planning of an orchard mower based on safe corridor and quadratic programming.

Introduction: Path planning algorithms are challenging to implement with mobile robots in orchards due to kinematic constraints and unstructured environments with narrow and irregularly distributed obstacles.

Methods: To address these challenges and ensure operational safety, a local path planning method for orchard mowers is proposed in this study. This method accounts for the structural characteristics of the mowing operation route and utilizes a path-velocity decoupling method for local planning based on following the global reference operation route, which includes two innovations.

Exosomal miRNA-21 derived from umbilical cord mesenchymal stem cells inhibits microglial overactivation to counteract nerve damage.

Background: Traumatic brain injury (TBI) is a major cause of neurological disability, and current treatments have limited effectiveness. Recent studies have emphasized the potential of exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs-Exo) in TBI treatment, but the molecular mechanisms underlying their therapeutic effects are not fully understood.

Methods And Results: In this study, UC-MSCs-Exo was isolated using ultracentrifugation and intraventricularly injected to TBI rat model.

Intraoperative Transfusion of Autologous Blood Protects from Acute Kidney Injury after Pediatric Congenital Heart Surgery.

Background: Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery. And autologous blood transfusion (ABT) is an important predictor of postoperative AKI. Unlike previous studies, which mainly focused on the correlation between ABT and AKI, the current study focuses heavily on the causal relationship between them, thus providing guidance for the treatment of patients during hospitalization to reduce the occurrence of AKI.

The efficacy of autologous matrix-induced chondrogenesis (AMIC) for osteochondral lesions of the talus in the mid-long term: a systematic review and meta-analysis.

Purpose: The objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions of the talus (OLT) using autologous matrix-induced chondrogenesis (AMIC), while also discussing the mid-long term functional outcomes, complications, and surgical failure rate.

Methods: We searched Embase, PubMed, and Web of Science for studies on OLT treated with AMIC with an average follow-up of at least 2 years. Publication information, patient data, functional scores, surgical failure rate, and complications were extracted.

Research Progress in High-Temperature-Resistant Electromagnetic Wire.

Electromagnetic wire is the carrier of energy and signal transmission. With the rapid development in aerospace, atomic energy, and other industrial fields, there is an increasing demand for the high-temperature-resistance of electromagnetic wires. In using traditional electromagnetic wires, it is difficult to meet the current temperature-resistance requirements.

Hardness Distribution and Growth Behavior of Micro-Arc Oxide Ceramic Film with Positive and Negative Pulse Coordination.

Micro-arc oxidation (MAO) is a promising technology for enhancing the wear resistance of engine cylinders by growing a high hardness alumina ceramic film on the surface of light aluminum engine cylinders. However, the positive and negative pulse coordination, voltage characteristic signal, hardness distribution characteristics of the ceramic film, and their internal mechanism during the growth process are still unclear. This paper investigates the synergistic effect mechanism of cathodic and anodic current on the growth behaviour of alumina, dynamic voltage signal, and hardness distribution of micro-arc oxidation film.

Comparing multiple infection control measures in a nursing home setting: a simulation study.

Objective: Compare the effectiveness of multiple mitigation measures designed to protect nursing home residents from infectious disease outbreaks.

Design: Agent-based simulation study.

Setting: Simulation environment of a small nursing home.

Total intracorporeal laparoscopic ileal ureter replacement in a single position for ureteral stricture based on membrane anatomy.

Purpose: The aim of this study was to present our initial experience and prove the feasibility of total intracorporeal laparoscopic ileal ureter replacement (TILIUR) in a single position for ureteral stricture based on membrane anatomy.

Materials And Methods: Between January 2021 and April 2023, six patients underwent TILIUR in a single position for ureteral strictures based on membrane anatomy. All patients with a past medical history underwent radical hysterectomy with bilateral pelvic lymph node dissection as well as extensive ureteral stricture due to radiotherapy.

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases.

Partial endothelial-to-mesenchymal transition (EndMT) is an intermediate phenotype observed in endothelial cells (ECs) undergoing a transition toward a mesenchymal state to support neovascularization during (patho)physiological angiogenesis. Here, we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4 (GTF2H4) as a positive regulator of this process. In addition, we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3 (ERCC3) to co-regulate partial EndMT.

A Patient Similarity Network (CHDmap) to Predict Outcomes After Congenital Heart Surgery: Development and Validation Study.

Background: Although evidence-based medicine proposes personalized care that considers the best evidence, it still fails to address personal treatment in many real clinical scenarios where the complexity of the situation makes none of the available evidence applicable. "Medicine-based evidence" (MBE), in which big data and machine learning techniques are embraced to derive treatment responses from appropriately matched patients in real-world clinical practice, was proposed. However, many challenges remain in translating this conceptual framework into practice.

The epidemiological characteristics of pediatric head injury in Hangzhou, China: a retrospective study based on cranial CT examinations.

Primary Objective: This study aims to create a pediatric head injury database based on cranial CT examinations and explore their epidemiologic characteristics.

Methods: Data related to cranial CT examinations of pediatric head injuries from March 2014 to March 2021 were collected at outpatient and emergency department of a pediatric medical center. The causes of injury, observable post-injury symptoms, and cranial injury findings were extracted with the assistance of natural language processing techniques.

RDmaster: A novel phenotype-oriented dialogue system supporting differential diagnosis of rare disease.

Background: Clinicians often lack the necessary expertise to differentially diagnose multiple underlying rare diseases (RDs) due to their complex and overlapping clinical features, leading to misdiagnoses and delayed treatments. The aim of this study is to develop a novel electronic differential diagnostic support system for RDs.

Method: Through integrating two Bayesian diagnostic methods, a candidate list was generated with enhance clinical interpretability for the further Q&A based differential diagnosis (DDX).

Intramedullary Nailing Versus Open Reduction and Plate Fixation for Lateral Malleolar Fractures: A Meta-Analysis.

The fixation for lateral malleolar fracture in ankle fractures is still controversial. The purpose of this meta-analysis is to compare clinical and radiological outcomes between intramedullary nail (IMN) and plate for lateral malleolar fractures in ankle fractures. The PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials (RCTs) from databases inception to June 2023.

Capturing Doublet Intermediate Emitters by Chemically Crosslinking Confinement towards Spatiotemporal Encryption.

Photoluminescence is one of the most meticulous ways to manipulate light energy. Typical photoluminescent emitters are mostly stable substances with a pure photophysical process of spontaneous photon-emission from their excited states. Intermediate emitters are elusive attributing to their synchronous energy transfer process including photophysical and incomplete photochemical pathways.

Research on the local path planning of an orchard mowing robot based on an elliptic repulsion scope boundary constraint potential field method.

In orchard scenes, the complex terrain environment will affect the operational safety of mowing robots. For this reason, this paper proposes an improved local path planning algorithm for an artificial potential field, which introduces the scope of an elliptic repulsion potential field as the boundary potential field. The potential field function adopts an improved variable polynomial and adds a distance factor, which effectively solves the problems of unreachable targets and local minima.