Publications by authors named "Haomin Guo"

Background: N-Methyladenosine (mA) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA mA modification in adult hippocampal neurogenesis remain enigmatic.

Results: We found that mA demethylase Alkbh3 was dramatically enriched in neurons and neuronal genesis.

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Article Synopsis
  • N-methylguanosine (mG) is a vital modification in mRNA that plays a key role in processes like mRNA export and translation, but its specific functions in adult neurogenesis and Alzheimer's disease are not fully understood.
  • The study investigated the effects of the mG methyltransferase complex Mettl1/Wdr4 on neuronal differentiation using various methods, revealing that Mettl1 enhances mG modification, promoting neurogenesis while its absence leads to decreased neuron formation and spatial memory deficits.
  • The research highlights the potential of targeting Mettl1 regulation of mG modification as a promising therapeutic strategy for treating Alzheimer's disease by improving neurogenesis.
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The surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) can be used to enhance the generation of the hot electrons in plasmon metal nanocavity. In this paper, Pd nanomembrane (NMB) is sputtered on the surface of Si nanosphere (NS) on glass substrate to form the Si@Pd core-Ω shell nanocavity. A plasmon-Mie resonance is induced in the nanocavity by coupling the plasmon resonance with the Mie resonance to control the optical property of Si NS.

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Realizing strong laser-matter interaction in a heterostructure consisting of two-dimensional transition metal dichalcogenides (TMDCs) and an optical nanocavity is a potential strategy for novel photonic devices. In this paper, two core-Ω shell nanostructures, Si@WS core-Ω shell nanostructure on glass/Si substrates, are briefly introduced. A strong laser-matter interaction occurred in the Si@WS core-Ω shell nanostructure when it was excited by femtosecond (fs) laser in the near-infrared-1 region (NIR-1, 650 nm-950 nm), resulting in a resonance coupling between the electric dipole resonance (EDR) of the Si nanosphere (NS) and the exciton resonance of the WS nanomembrane (NMB).

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Charge transport in insulating composites is fundamental to designing high performance in electrical breakdown strength processes. A fundamental understanding of the charge transport at nanoscale in insulating composites remains elusive. Herein, we fabricate two types of interfaces in epoxy (EP) composites (AlO/EP and bubble/EP, respectively).

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In this study, the influence of the geometric parameters on the optical absorption of gallium arsenide [GaAs] nanowire arrays [NWAs] has been systematically analyzed using finite-difference time-domain simulations. The calculations reveal that the optical absorption is sensitive to the geometric parameters such as diameter [D], length [L], and filling ratio [D/P], and more efficient light absorption can be obtained in GaAs NWAs than in thin films with the same thickness due to the combined effects of intrinsic antireflection and efficient excitation of resonant modes. Optimized geometric parameters are obtained as follows: D = 180 nm, L = 2 μm, and D/P = 0.

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