Publications by authors named "Haomiao Lan"
Background: The purpose of this study was to investigate the potential of plasma cfDNA methylation patterns in reflecting tumour methylation changes, focusing on three candidate sites, cg02469161, cg11528914, and cg20131654. These sites were selected for verification, with a particular emphasis on their association with breast cancer.
Methods: We conducted a comprehensive analysis of 850k whole-methylation sequencing data to identify potential markers for breast cancer detection.
Article Synopsis
- Breast cancer, especially estrogen receptor-positive (ER) subtype, poses significant treatment challenges due to current therapies' side effects; this study investigates Chrysin, a natural flavonoid with potential benefits for ER breast cancer, using mesoporous dopamine nanoparticles (mPDA) for improved delivery and efficacy.
- * Researchers synthesized and characterized Chrysin-loaded mPDA nanoparticles, evaluated their effectiveness in animal models, and utilized network pharmacology to understand Chrysin's mechanisms and validate findings through gene expression analysis.
- * Results showed that Chrysin@mPDA nanoparticles effectively released the drug when exposed to laser irradiation, leading to reduced tumor volume and weight, decreased estrogen receptor-positive cells, and increased immune cell infiltration, demonstrating promise for
circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis.
Cell Mol Biol (Noisy-le-grand)
March 2024
Circular RNAs (circRNAs) are engaged in various types of cancers. This study aimed to investigate the roles of circ_0006743 (circ_JMJD1C) in breast cancer. The downstream of circ_JMJD1C and their interaction network was determined by bioinformatic analyses.
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- A 28-year-old man with papillary thyroid cancer had a bone scan to check for possible spread to his bones.
- He had intense workouts just before the scan, focusing on various muscle groups.
- The scan revealed increased activity only in the rectus abdominis, with no signs of bone lesions or issues in other muscles.