Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death.

Despite the initial efficacy of enzalutamide in castration-resistant prostate cancer (CRPC), inevitable resistance remains a significant challenge. Here, the synergistic induction of copper-dependent cell death (cuproptosis) in CRPC cells is reported by enzalutamide and copper ionophores (elesclomol/disulfiram). Mechanistically, enzalutamide treatment increases mitochondrial dependence in CRPC cells, rendering them susceptible to cuproptosis, as evidenced by specific reversal with the copper chelator tetrathiomolybdate.

A meta-analysis of postoperative wound complications at the surgical site in prostate cancer patients undergoing robotic surgery.

This meta-analysis critically evaluates the role of robotic surgery in reducing postoperative wound complications in prostate cancer patients, comparing it with traditional open and laparoscopic approaches. Our extensive literature search resulted in 9 studies comprising 2063 patients. The results highlighted a significant reduction in the incidence of wound complications, with an 84% heterogeneity index and a standardized mean difference (SMD) of 0.

Differences in selenium concentration and bioavailability between paddy and dryland soils of China: A study based on literature collection and field sampling.

Lack systematic understanding of differences in environmental behavior of selenium between paddy and dryland soils affects Se biofortification and leads to human Se-related health risks. Therefore, this study investigated differences in Se concentration and bioavailability between paddy and dryland soils using data collected from literatures and field sampling. Our analysis showed paddy soil Se concentration in Se-rich area of China was significantly lower than that in dryland soil.

Electrochemical immunosensor based on hyperbranched structure for carcinoembryonic antigen detection.

Sensitive determination of carcinoembryonic antigen (CEA) is very important in clinical research and diagnosis. Herein we report the design and synthesis of a new kind of immunosensor based on the benefits of hyperbranched structure. The hyperbranched polyester was grafted to the surface of indium tin oxides glass (ITO) electrode, and the grafting processes were characterized by attentuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM).

Preparation of hemocompatible cellulosic paper based on P(DMAPS)-functionalized surface.

The surface-modification of paper substrates with functional layers is gaining increasing interest, both from academic and industrial research. In this case, the cellulosic paper (CP) surface was functionalized with zwitterionic poly-(3-dimethyl(methacryloyloxyethyl) ammoniumpropane sulfonate) (CP-g-P(DMAPS) via surface-initiated atom transfer radical polymerization (ATRP) technique for enhancing blood compatibility. An obvious increase in graft yield of the functional P(DMAPS) with polymerization time was observed.

Fabrication of nonbiofouling metal stent and in vitro studies on its hemocompatibility.

In recent years, there has been increasing interest for the surface modification of biomaterials in order to improve their surface properties. The bare metal stents surface based on 3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate polymers has shown an excellent antifouling and blood compatibility by using surface-initiated atom transfer radical polymerization. Surface structure, morphology, wettability, and element content were characterized by scanning electronic microscope, static water contact angles measurement, X-ray photoelectron spectroscopy measurement, respectively.