Publications by authors named "Haolin Yang"

Cancer seriously threatens human life and health, and the structure and function of genes within cancer cells have changed relative to normal cells. Essentially, cancer is a polygenic disorder, and the core of its occurrence and development is caused by polygenic synergy. Non-coding RNAs (ncRNAs) act as regulators to modulate gene expression levels, and they provide theoretical basis and new technology for the diagnosis and preventive treatment of cancer.

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Background: The prevalence of diabetic cognitive impairment (DCI) is significant, some studies have shown that it is related to mitochondrial respiratory chain homeostasis, but the specific mechanism is not clear. 2-hydroxyisobutyric acid (2-HIBA) is a novel short-chain fatty acid with potential applications in the treatment of metabolic diseases because it can regulate mitochondrial disorders. Our aim was to explore a novel mechanism of action for 2-HIBA in the treatment of DCI in mitochondrial respiratory chain homeostasis.

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Aquatic nitrogenous compounds can be classified as dissolved organic nitrogen (DON) and dissolved inorganic nitrogen (DIN), including ammonia, nitrite, nitrate, and inorganic chloramines. The occurrence of nitrogenous disinfection byproducts (N-DBPs) in water, such as haloacetonitriles (HANs), halonitromethanes (HNMs), haloacaetamides (HAcAms), and nitrosamines (NAs), has attracted considerable attention due to their higher toxicity than regulated carbonaceous analogues. While numerous studies have investigated the contributions of DON to N-DBP formation, relatively fewer studies have explored DIN as N-DBP precursors, although DINs are sometimes evaluated as influencing factors.

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The in-plane folding wing is one of the important research directions in the field of morphing or bionic aircraft, showing the unique application value of enhancing aircraft maneuverability and gust resistance. This article provides a structural realization of an in-plane folding wing and an aeroelasticity modeling method for the folding process of the wing. By approximating the change in structural properties in each time step, a method for calculating the structural transient response expressed in recursive form is obtained.

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Article Synopsis
  • Autism spectrum disorder (ASD) is a complex condition with high genetic diversity, and long non-coding RNAs (lncRNAs) play crucial roles in its neurological mechanisms, which current methods often fail to analyze at the cell type level.
  • The study introduces a new approach called Cycle, which creates a detailed map of lncRNA regulation specifically for different ASD cell types, revealing that each has unique regulatory patterns.
  • Findings indicate that more than one-third of the lncRNA networks are scale-free and small-world, with connections between similar ASD cell types being stronger, positioning Cycle as a valuable tool for exploring the diverse lncRNA regulation in ASD.
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Article Synopsis
  • MicroRNA sponges play a significant role in regulating both normal and disease-related biological processes, often working in groups or clusters.
  • The text introduces a protocol using the R package miRSM 2.0 for identifying and analyzing these miRNA sponge modules in various data sets.
  • This computational tool aims to enhance our understanding of how miRNA sponges are involved in diseases, with further details provided in the mentioned reference to Zhang et al.
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The scaling of bulk Si-based transistors has reached its limits, while novel architectures such as FinFETs and GAAFETs face challenges in sub-10 nm nodes due to complex fabrication processes and severe drain-induced barrier lowering (DIBL) effects. An effective strategy to avoid short-channel effects (SCEs) is the integration of low-dimensional materials into novel device architectures, leveraging the coupling between multiple gates to achieve efficient electrostatic control of the channel. We employed TCAD simulations to model multi-gate FETs based on various dimensional systems and comprehensively investigated electric fields, potentials, current densities, and electron densities within the devices.

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Background: Osteoporosis is a major health issue. MicroRNAs (miRNAs) play multiple roles in regulating cell growth and development. High-throughput sequencing technology is widely used nowadays.

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Here, we propose a self Q-switched single-frequency (SF) all-fiber laser. The intra-cavity Er:Yb co-doped fiber serves not only as an active fiber for lasing but also as a fiber-type saturable absorber (SA). The self-Q-switching behavior is induced by the ground-state reabsorption of the unpumped portion of the active fiber.

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Musculoskeletal diseases (MSDs), including osteoarthritis (OA), osteosarcoma (OS), multiple myeloma (MM), intervertebral disc degeneration (IDD), osteoporosis (OP), and rheumatoid arthritis (RA), present noteworthy obstacles associated with pain, disability, and impaired quality of life on a global scale. In recent years, it has become increasingly apparent that N6-methyladenosine (m6A) is a key regulator in the expression of genes in a multitude of biological processes. m6A is composed of 0.

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Biological control of pests and pathogens has attracted much attention due to its green, safe and effective characteristics. However, it faces the dilemma of insignificant effects in large-scale applications. Therefore, an in-depth exploration of the metabolic potential of biocontrol fungi based on big omics data is crucial for a comprehensive and systematic understanding of the specific modes of action operated by various biocontrol fungi.

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Nanoplastic water contamination has become a critical environmental issue, highlighting the need for rapid and sensitive detection of nanoplastics. In this study, we aimed to prepare a graphene oxide (GO)/multiwalled carbon nanotube (MWCNT)-silver nanostar (AgNS) multifunctional membrane using a simple vacuum filtration method for the enrichment and surface-enhanced Raman spectroscopy (SERS) detection of polystyrene (PS) nanoplastics in water. AgNSs, selected for the size and shape of nanoplastics, have numerous exposed Raman hotspots on their surface, which exert a strong electromagnetic enhancement effect.

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The advancement of spatial interaction technology has greatly enriched the domain of consumer electronics. Traditional solutions based on optical technologies suffers high power consumption and significant costs, making them less ideal in lightweight implementations. In contrast, ultrasonic solutions stand out due to their lower power consumption and cost-effectiveness, capturing widespread attention and interest.

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Background: Breast cancer bone metastasis is closely associated with the bone microenvironment. Zuogui Pill (ZGP), a clinically approved formulation in China, effectively regulates the bone microenvironment for the prevention and treatment of osteoporosis.

Purpose: Few reports have utilized the ZGP for bone metastasis models.

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At present, flexible pressure-sensitive materials generally have problems with weak adhesion and poor wear resistance, which easily result in friction failure when used for plantar pressure detection. In this study, a flexible pressure sensor with the advantages of a wide detection range, fast recovery, and good abrasive resistance was designed and prepared based on the screen printing process. The pressure-sensitive unit with a structural size of 5 mm× 8 mm was a functional material system due to the use of graphene and epoxy resin.

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This paper presents a novel bimorph Piezoelectric Micromachined Ultrasonic Transducer (PMUT) fabricated with 8-inch standard CMOS-compatible processes. The bimorph structure consists of two layers of 20% scandium-doped aluminum nitride (ScAlN) thin films, which are sandwiched among three molybdenum (Mo) layers. All three Mo layers are segmented to form the outer ring and inner plate electrodes.

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Here, we report an all-fiber tunable ultrafast Raman laser synchronously pumped by a home-made 1.6 µm dissipative soliton (DS) picosecond (ps) laser, which produces Stokes light beyond 1.7 µm.

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Compared to conventional ultrasonic flowmeters using multiple transducers, this paper reports, for the first time, an airflow volumetric flowmeter using a signal PMUT array to measure the flow rate in a rectangular pipe. The PMUT around 200 kHz is selected to fit the system requirements. All PMUT elements on this single array are then electrically grouped into transmitter and receiver.

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Piezoelectric micromachined ultrasonic transducers (PMUTs) have been widely applied in distance sensing. However, the sensing distance of currently reported miniaturized ultrasonic sensors (e.g.

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Understanding the water content variations in Yunnan laterite (red loam soil, SR) in small-scale environments and exploring the potential for crop water-use efficiency (WUE) improvement are crucial for improving water-saving irrigation technologies used in greenhouse agriculture in Yunnan, China. In this study, a closed-loop model for calculating soil water in greenhouse potted cultivation was established based on water conservation. A Yunnan SR, yellow sand soil (SY), and a 1:1 SR-SY mixture (SM) subjected to root-zone micro-irrigation or surface-drip irrigation were experimentally examined to compare their water content variations and pepper WUEs.

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Although phosphate (Pi) is a necessary nutrient for the growth of aquatic organisms, the presence of excess Pi leads to water eutrophication; thus, it is necessary to accurately determine the content of Pi in water. A method for the determination of trace Pi in aquaculture water was developed based on surface-enhanced Raman spectroscopy (SERS) combined with rhodamine 6G (R6G)-modified silver nanoparticles (AgNPs) as the active substrate. The adsorption of R6G on the AgNP surfaces led to a strong SERS signal.

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A laser diode (LD) pumped intracavity chemical vapor deposition (CVD) diamond cascade Raman laser is reported here. By rotating a Brewster plate (BP) in the laser resonator, the Raman laser with tunable output coupling rate is achieved. The highly compact diamond laser emitted 1240 nm and 1485 nm Stokes light simultaneously via optimization of the pumping direction.

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Background: Since the outbreak of COVID-19, the number of COVID-19 patients has been on the rise. With the improvement of diagnosis and treatment level in various countries, more and more patients have recovered. Baduanjin exercise is a traditional Chinese health care method with a long history, easy-to-learn, and remarkable effect.

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A disease known as covert mortality disease has become an increasing problem in the shrimp farming industry in recent years in China and several countries of Southeast Asia, leading to serious losses in production. Litopenaeus vannamei (also known as Pacific white shrimp) is affected by this disease that leads to a range of clinical symptoms including hepatopancreas atrophy and necrosis, soft shell, slow growth, and abdominal muscle whitening and necrosis in the acute stage of disease. A new nodavirus, termed covert mortality nodavirus (CMNV), has been shown to be the etiological agent.

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A new nodavirus, named covert mortality nodavirus (CMNV), is associated with covert mortality disease of shrimp which has caused serious loss in China since 2009. Histopathological examination of shrimp suffering the disease revealed coagulative necrosis of striated muscle similar to typical histopathology features of infectious myonecrosis virus (IMNV), Penaeus vannamei nodavirus (PvNV) and Macrobrachium rosenbergii nodavirus (MrNV). However, shrimp suffering this disease tested negative for IMNV, MrNV and PvNV by reverse transcription (RT)-PCR.

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