Due to the detrimental impact of steel industry emissions on the environment, countries worldwide prioritize green development. Replacing sintered iron ore with pellets holds promise for emission reduction and environmental protection. As high-grade iron ore resources decline, research on limonite pellet technology becomes crucial.
View Article and Find Full Text PDFProteinśprotein interaction (PPI) between lens epithelium-derived growth factor (LEDGF/p75) and human immunodeficiency virus (HIV) integrase (IN) becomes an attractive target for anti-HIV drug development. The blockade of this interaction by small molecules could potentially inhibit HIV-1 replication. In this study, a panel of 99 structurally related flavonoids were was tested, concerning their ability to inhibit IN-LEDGF/p75 interaction, using a homogeneous time time-resolved fluorescence (HTRF) assay.
View Article and Find Full Text PDFFour undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2, 4)-sinkiangenoxide C, and (2, 4)-sinkiangenoxide C (1: - 4: ), and one known compound, 1-(methylthio)propyl ()-1-propenyl disulfide (5: ), were isolated from the resin of . Their structures were determined based on spectroscopic methods, including IR, UV, HRESIMS, NMR, and CD analysis. Compounds 2: - 4: showed moderate cytotoxic activities against four human cancer cell lines with IC values ranging from 15.
View Article and Find Full Text PDFLens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs). In this study, compound libraries were screened to identify new inhibitors of LEDGF/p75-IN interaction.
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