Identification and validation of a prognostic risk model based on radiosensitivity-related genes in nasopharyngeal carcinoma.

Background: Despite advancements with intensity-modulated radiation therapy (IMRT), about 10 % of nasopharyngeal carcinoma (NPC) patients remain resistant to radiotherapy, leading to recurrence and poor prognosis. This study aims to identify radiosensitivity-related genes in NPC and develop a prognostic model to predict patient outcomes.

Methods: We analyzed 179 NPC samples from Fujian Cancer Hospital using RNA sequencing.

Cost-Effective DNA Storage System with DNA Movable Type.

In the face of exponential data growth, DNA-based storage offers a promising solution for preserving big data. However, most existing DNA storage methods, akin to traditional block printing, require costly chemical synthesis for each individual data file, adopting a sequential, one-time-use synthesis approach. To overcome these limitations, a novel, cost-effective "DNA-movable-type storage" system, inspired by movable type printing, is introduced.

Distribution and adsorption-desorption of organophosphate esters from land to sea in the sediments of the Beibu Gulf, South China Sea: Impact of seagoing river input.

Organophosphate esters (OPEs) have been a class of emerging environmental contaminants. However, studies on their environmental behavior, specifically their adsorption-desorption behavior between sediment and seawater in estuarine and coastal areas, remain limited. To address this gap, our study focused on investigating the levels and behavior of 11 OPEs in sediment samples collected from the Beibu Gulf, South China Sea, encompassing estuaries and coastal regions.

Functionalized Nanomaterials Capable of Crossing the Blood-Brain Barrier.

The blood-brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics.

Sources of the Elevating Polycyclic Aromatic Hydrocarbon Pollution in the Western South China Sea and Its Environmental Implications.

The environmental implications of polycyclic aromatic hydrocarbons (PAHs) caused by the vigorous development of offshore oil exploitation and shipping on the marine ecosystem are unclear. In this study, the PAH concentrations were systematically characterized in multiple environmental media (i.e.

Black Carbon in Deep-Sea Seamount Sediment Cores: Vertical Variation and Non-negligible Char Black Carbon.

Deep-sea sediments (>1000 m) are often considered to be the ultimate sink for black carbon (BC), and the long-term buried BC in these sediments is believed to potentially provide a negative feedback effect on climate warming. The burial flux of BC in marine sediments is predominantly estimated based on soot BC (SBC) in most studies, frequently ignoring the contribution of char BC (CBC). While this methodology may result in an underestimation of the BC burial flux, the precise extent of this underestimation is yet to be determined.

Organophosphate esters (OPEs) in a coral reef food web of the Xisha Islands, South China Sea: Occurrence, trophodynamic, and exposure risk.

Despite organophosphate esters (OPEs) are widely prevalent in the environment, however, limited information is available regarding their occurrence, trophodynamics, and exposure risks in coral reef ecosystems. In this study, 11 OPEs were investigated in a tropical marine food web (7 fish species and 9 benthos species) from the Xisha (XS) Islands, South China Sea (SCS). The ∑OPEs were 1.

Chirality-controlled polymerization-induced self-assembly.

Recent studies have shown that biodegradable nanoparticles can be efficiently prepared with polymerization of -carboxyanhydrides-induced self-assembly (NCA-PISA). However, thus far, the effect of chiral monomer ratio on such NCA-PISA formulations and the resulting nanoparticles has not yet been fully explored. Herein, we show, for the first time, that the morphology, secondary structure, and biodegradation rate of PISA nanoparticles can be controlled by altering the chiral ratio of the core-forming monomers.

Polymeric Dendrimers as Nanocarrier Vectors for Neurotheranostics.

Dendrimers are polymers with well-defined 3D branched structures that are vastly utilized in various neurotheranostics and biomedical applications, particularly as nanocarrier vectors. Imaging agents can be loaded into dendrimers to improve the accuracy of diagnostic imaging processes. Likewise, combining pharmaceutical agents and anticancer drugs with dendrimers can enhance their solubility, biocompatibility, and efficiency.

Bioaccumulation and trophic transfer of PAHs in tropical marine food webs from coral reef ecosystems, the South China Sea: Compositional pattern, driving factors, ecological aspects, and risk assessment.

Multiple environmental pressures caused by global warming and human activities have aroused widespread concern about PAHs pollution in tropical marine coral reef regions (CRRs). However, the trophodynamics of PAHs in the food webs of the CRRs and the related influence factors have not been reported. This study investigated the occurrence, trophic amplification, and transmission of PAHs in various organisms selecting between at least representative species for each level in CRRs of the South China Sea (SCS); revealed their driving mechanisms; and explored the trophodynamics of PAHs in the food web of the coral reef ecosystem.

Expression and role of ABIN1 in sepsis: and studies.

[This retracts the article DOI: 10.1515/med-2021-0008.].

Changes in the intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei) with different severities of Enterocytozoon hepatopenaei infection.

The intestinal microbiota of the Pacific white shrimp Litopenaeus vannamei during Enterocytozoon hepatopenaei (EHP) infection was investigated by 16S rRNA gene-based analysis. The results showed that bacterial diversity in the intestine of L. vannamei was high, but it decreased with increasing severity of EHP infection.

Organic Nanoparticles Based on D-A-D Small Molecule: Self-Assembly, Photophysical Properties, and Synergistic Photodynamic/Photothermal Effects.

Cancer is one of the major diseases threatening human health. Traditional cancer treatments have notable side-effects as they can damage the immune system. Recently, phototherapy, as a potential strategy for clinical cancer therapy, has received wide attention due to its minimal invasiveness and high efficiency.

Toxicity of avermectin to Eriocheir sinensis and the isolation of a avermectin-degrading bacterium, Ochrobactrum sp. AVM-2.

Avermectin is widely used in the prevention and treatment of parasites diseases in aquaculture. However, the residual avermectin has a serious impact on the growth and quality of aquatic animals including Eriocheir sinensis. This study shows that the LC of avermectin to E.

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy.

Phototherapy has gained great attention in the past decade owing to the advantages of high selectivity and low toxicity. However, it's still a challenge to develop a single photosensitizer that can achieve both photothermal and photodynamic effects. Herein, we design and synthesize a new organic compound (PIT) with a typical D-A-D structure through the covalent conjugation of perylene diimides (PDI) and triphenylamine (TPA).

Expression and role of ABIN1 in sepsis: and studies.

In this research, we attempted to explain the effect and the related molecular mechanisms of ABIN1 in lipopolysaccharide (LPS)-induced septic mice or RAW264.7 macrophages. LPS was adopted to treat RAW264.

Self-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment.

Near-infrared (NIR) light-activated phototherapy, such as photothermal therapy (PTT) and photodynamic therapy (PDT), has gained considerable attention due to the advantages of high efficiency and minimally invasiveness. However, the development of a single component therapeutic agent with clear structure and molecular weight that achieve photodynamic/photothermal synergistic therapy is still challenging. Herein, we design and synthesize a new smart photosensitizer (PRX) by conjugation of perylene diimide (PDI) and methylene violet (RAX).

A Simple Strategy to Fabricate Phthalocyanine-Encapsulated Nanodots for Magnetic Resonance Imaging and Antitumor Phototherapy.

Photothermal agents can transfer the absorbed light to heat energy, offering a noninvasive and controllable method to kill tumor cells and tissues. Here, we develop a simple and high-output strategy to prepare photothermal nanodots (MnPc-NDs) by the self-assembly and carbonization of manganese phthalocyanine. The aggregation of phthalocyanine molecules in the nanodots induces an efficient photothermal conversion.

RETRACTED: Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).

Brain neural effects of the 'tonifying kidney and benefiting marrow' method in the treatment of osteoporosis.

In Traditional Chinese Medicine (TCM), the 'tonifying kidney and benefiting marrow' (TKBM) method is based on the theory that kidney controls bones, while marrow moistens bones. There have been aboundant theoretical studies on kidney controlling bones since Huangdi's Internal Classics. However, there are too few ones about the marrow moistening the bones.

Self-Assembled Naphthalimide Conjugated Porphyrin Nanomaterials with D-A Structure for PDT/PTT Synergistic Therapy.

Light-activated phototherapy, including photothermal and photodynamic therapy, has become a new way for spatiotemporal control and noninvasive treatment of cancer. In this study, two new organic porphyrin molecules ( and ) with donor (D)-acceptor (A) structure were designed and synthesized. The donor-acceptor pairs facilitated the intermolecular electron transfer, resulting in the enhancement of near-infrared (NIR) absorbance and nonradiative heat generation.