Publications by authors named "Haokun Tong"

Atherosclerosis (AS) represents a prevalent initiating factor for cardiovascular events. Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) is an oncofetal RNA-binding protein that participates in cardiovascular diseases. This work aimed to elaborate the effects of IGF2BP3 on AS and the probable mechanism by using an oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs) model.

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Article Synopsis
  • Atherosclerosis (AS) is a condition that causes plaque buildup in arteries due to lipid metabolism issues, and SESN1 is a protein that may help regulate this process.
  • Researchers used mouse models and human cell models to study the effects of SESN1 overexpression, finding that it reduced plaque formation, endothelial damage, and inflammation in AS.
  • The study concluded that SESN1 helps protect against endothelial ferroptosis (a form of cell death) in AS by activating a protein called P21.
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