Acylated Inulin as a Potential Shale Hydration Inhibitor in Water Based Drilling Fluids for Wellbore Stabilization.

Shale hydration dispersion and swelling are primary causes of wellbore instability in oil and gas reservoir exploration. In this study, inulin, a fructo-oligosaccharide extracted from Jerusalem artichoke roots, was modified by acylation with three acyl chlorides, and the products (C10-, C12-, and C14-inulin) were investigated for their use as novel shale hydration inhibitors. The inhibition properties were evaluated through the shale cuttings hot-rolling dispersion test, the sodium-based bentonite hydration test, and capillary suction.

Robust Hydrogel Actuators Functioning in Multi-Environments Enabled by Thermo-Responsive Polymer Nanoparticle Coatings on Hydrogel Surfaces.

Hydrogel actuators with anisotropic structures exhibit reversible responsiveness upon the trigger of various external stimuli, rendering them promising for applications in many fields including artificial muscles and soft robotics. However, their effective operation across multiple environments remains a persistent challenge, even for widely studied thermo-responsive polymers like poly(N-isopropyl acrylamide) (PNIPAm). Current attempts to address this issue are hindered by complex synthetic procedures or specific substrates.

Effect of Low Gravity Solids on Weak Gel Structure and the Performance of Oil-Based Drilling Fluids.

Drilling cuttings from the rock formation generated during the drilling process are generally smashed to fine particles through hydraulic cutting and grinding using a drilling tool, and then are mixed with the drilling fluid during circulation. However, some of these particles are too small and light to be effectively removed from the drilling fluid via solids-control equipment. These small and light solids are referred to as low gravity solids (LGSs).

Styrene-Lauryl Acrylate Rubber Nanogels as a Plugging Agent for Oil-Based Drilling Fluids with the Function of Improving Emulsion Stability.

With the exploration and development of unconventional oil and gas, the use frequency of oil-based drilling fluid (ODF) is increasing gradually. During the use of ODFs, wellbore instability caused by invasion of drilling fluid into formation is a major challenge. To improve the plugging property of ODFs, nano-sized poly(styrene-lauryl acrylate) (PSL) rubber nanogels were synthesized using styrene and lauryl acrylate through soap-free emulsion polymerization method and were characterized using FTIR, NMR, SEM, TEM, particle size analysis and TGA.

A Thermal-Responsive Zwitterionic Polymer Gel as a Filtrate Reducer for Water-Based Drilling Fluids.

It is crucial to address the performance deterioration of water-based drilling fluids (WDFs) in situations of excessive salinity and high temperature while extracting deep oil and gas deposits. The focus of research in the area of drilling fluid has always been on filter reducers that are temperature and salt resistant. In this study, a copolymer gel (PAND) was synthesized using acrylamide, N-isopropyl acrylamide, and 3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate through free-radical polymerization.

LACpG10-HL Functions Effectively in Antibiotic-Free and Healthy Husbandry by Improving the Innate Immunity.

Antibiotics are broadly restricted in modern husbandry farming, necessitating the need for efficient and low-cost immunomodulatory preparations in antibiotic-free and healthful farming. As is known to all, CpG oligonucleotides (CpG-ODNs, an effective innate immunostimulatory agent) recognized by TLR9 in mammals (while TLR21 in avians) could collaborate with some united agent to induce stronger immune responses, but the cost is prohibitively expensive for farmers. Here, considering the coordination between TLR2 and TLR9/TLR21, we firstly proposed the idea that the well-fermented could be utilized as a CpG-plasmid carrier (LACpG10) to enhance the host's innate immunity against pathogenic invasion.

Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases.

Intestinal homeostasis is a dynamic balance involving the interaction between the host intestinal mucosa, immune barrier, intestinal microecology, nutrients, and metabolites. Once homeostasis is out of balance, it will increase the risk of intestinal diseases and is also closely associated with some systemic diseases. Probiotics ( Nissle 1917, , , lactic acid bacteria and spp.

YBX has functional roles in CpG-ODN against cold stress and bacterial infection of Misgurnus anguillicaudatus.

Misgurnus anguillicaudatus (M. anguillicaudatus) is a widely cultivated fish. However, in M.

Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway.

Clostridium butyricum (C. butyricum) is a probiotic that could promote animal growth and protect gut health. So far, current studies mainly keep up with the basic biological functions of C.

Intestinal guard: Human CXCL17 modulates protective response against mycotoxins and CXCL17-mimetic peptides development.

Mycotoxin contamination is an ongoing and growing issue that can create health risks and even cause death. Unfortunately, there is currently a lack of specific therapy against mycotoxins with few side effects. On the other hand, the strategic expression of CXCL17 in mucosal tissues suggests that it may be involved in immune response when exposed to mycotoxins, but the exact role of CXCL17 remains largely unknown.

Protective effects of Clostridium butyricum against oxidative stress induced by food processing and lipid-derived aldehydes in Caco-2 cells.

The human body is almost always facing the oxidative stress caused by foodborne aldehydes such as glyoxal (GO) and methylglyoxal (MGO), 4-hydroxyhexenal (HHE), and 4-hydroxynonenal (HNE). When these aldehydes build up, they can cause a range of harm. However, a probiotic, Clostridium butyricum, can increase nuclear factor erythroid-2 related factor 2 (Nrf2) and may have the potential to relieve oxidative stress.

Molecular cloning, characterization and expression profiles of Annexin family (ANXA1~A6) in yellow catfish (Pelteobagrus fulvidraco) and ANX regulation by CpG ODN responding to bacterial infection.

Up to now, many previous reports have emphasized that Annexins (ANX) family played an important role in immune responses. Aeromonas hydrophila (A. hydrophila), the most common zoonotic pathogenic bacteria of yellow catfish (Pelteobagrus fulvidraco), can cause serious economic loss, especially to yellow catfish with high economic value.

Nanoscale Laponite as a Potential Shale Inhibitor in Water-Based Drilling Fluid for Stabilization of Wellbore Stability and Mechanism Study.

Shale hydration is the main reason causing wellbore instability in oil and gas drilling operations. In this study, nanoscale laponite as a shale inhibitor was employed to stabilize wellbores. The inhibition property of laponite suspensions was evaluated by an immersion experiment, linear swelling measurement, and a shale recovery test.

An alternative method to enhance w/o emulsion stability using modified dimer acid and its application in oil based drilling fluids.

This study presents an alternative method to enhance the emulsion stability of oil based drilling fluids (OBMs). Modified dimer acid (MDA) was synthesized with a molecular structure having two hydrophilic heads and two hydrophobic tails. Theoretically, the adsorption of MDA on an oil-water interface makes it possible to increase hydrogen bonding between water droplets and form three dimensional networks which benefit emulsion stability.