Precipitation versus dissolution at the phosphorus and Solanum nigrum L. root exudate interface: Implications for lead rebound in rhizosphere soils.

Lead (Pb) rebound in the root-zone of plants is a primary risk associated with rhizosphere effect in phosphorus (P)-amended vegetated soils. Herein, we investigated the differential effects of root exudates (RE) from Solanum nigrum L. on Pb availability under conditions with variable P mineral forms.

A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy.

Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials are being utilized more frequently in periodontal therapy due to their designability and unique drug delivery system. However, local and systemic immune response reactions driven by the implantation of biomaterials could result in inflammation, tissue damage, and fibrosis, which could end up with the failure of the implantation.

Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway.

Xenogeneic extracellular matrices (xECM) for cell support have emerged as a potential strategy for addressing the scarcity of donor matrices for allotransplantation. However, the poor survival rate or failure of xECM-based organ transplantation is due to the negative impacts of high-level oxidative stress and inflammation on seed cell viability and stemness. Herein, we constructed xenogeneic bioengineered tooth roots (bio-roots) and used extracellular vesicles from human adipose-derived mesenchymal stem cells (hASC-EVs) to shield bio-roots from oxidative damage.

Family function, anxiety and depression in adults with disabilities: a network analysis.

Background: The prevalence of family dysfunction, anxiety and depression is high in people with disabilities due to long-term activity constraints and social difficulties. Recently, although studies have attempted to provide guidance for family therapy by focusing on the relationship between family function and negative emotions, the specific effects of improved family function during family therapy on alleviation of anxiety and depressive symptoms have been obscured. Thus, this study attempted to elucidate the impact of specific family functioning on specific symptoms of anxiety and depression through network analysis.

Risk Perception and Public Pandemic Fatigue: The Role of Perceived Stress and Preventive Coping.

Purpose: This study explores the status of pandemic fatigue, predictors, and their mechanisms of action based on a stress-response framework and a parallel model of future-oriented response.

Patients And Methods: Study 1 investigated 8426 Chinese adult residents' understanding of and willingness to cooperate with the pandemic prevention and control policies and Study 2 surveyed 1635 Chinese residents on their activeness of pandemic prevention and control (APPC), pandemic risk perception, perceived stress, and future-oriented coping.

Results: Study 1 found that public understanding of and willingness to cooperate with prevention policies were significantly lower in 2022 than in 2020 and 2021.

Relationship between Depression and Cognitive Inhibition in Men with Heroin or Methamphetamine Use Disorder in First-Time Mandatory Detoxification.

Previous studies have shown that males with substance use disorder (SUD) in their first mandatory detoxification experience high rates of depression. It is unknown whether this high depression incidence contributes to impaired inhibition. In this work, two studies were undertaken to examine the role of depression in cognitive inhibition in heroin and methamphetamine withdrawal.

Effect of social support on anxiety of medical staff one year after COVID-19 outbreak: a moderated mediating model.

One year after the outbreak of COVID-19, medical staff are facing high anxiety due to multiple work stresses. Social support has become a protective factor for healthcare workers' anxiety symptoms, but the exact mechanism of action is not yet known. Based on the buffering model, this study aims to explore the impact and mechanisms of action of healthcare workers' perception of social support (PSS) on anxiety symptoms in the context of the epidemic and to further explore how the emotional characteristics of risk perception (ECRP) and resilience play their influence.

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma.

Glaucoma is a highly heritable disease that is a leading cause of blindness worldwide. Here, we identified heterozygous thrombospondin 1 (THBS1) missense alleles altering p.Arg1034, a highly evolutionarily conserved amino acid, in 3 unrelated and ethnically diverse families affected by congenital glaucoma, a severe form of glaucoma affecting children.

COVID-19 vaccine hesitancy and GAD: The role of risk perception and vaccination status.

Background And Purpose: As Coronavirus disease (COVID-19) continues to spread around the world, COVID-19 vaccines are the most effective weapons against the global pandemic. Yet vaccine hesitancy remains a serious problem and can pose certain hazards to individuals' mental health, such as rising anxiety. Therefore, based on Self-Discrepancy Theory, this paper aims to explore the role of COVID-19 vaccine hesitancy on individual generalized anxiety disorder and its influence mechanisms through two studies.

Inhibition of Wnt Signaling in Colon Cancer Cells via an Oral Drug that Facilitates TNIK Degradation.

We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types of cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 suppresses colorectal cancer growth by interfering with the Wnt signaling pathway, a main driver of cell growth in colorectal cancer. Specifically, we find that OBD9 induces autophagic degradation of TNIK (traf2 and Nck-interacting kinase), which promotes T-cell factor-4 (TCF4)/beta-catenin-mediated gene expression.

Performance of oxalate-doped hydroxyapatite as well as relative contribution of oxalate and phosphate for aqueous lead removal.

An oxalate-doped hydroxyapatite (O-HAP) was hydrothermally synthesized for aqueous lead (Pb) removal based on the solubility-limiting ability of oxalate and phosphate over pH range 4-9. Free Pb activities in oxalate and/or phosphate systems were controlled by oxalate to form soluble ion pairs Pb-Ox (aq) and Pb-Ox at pH 4-7 while in preference to persist as PbHPO (aq) when pH ≥ 8. Both phosphate and oxalate exhibited excellent efficiency in reducing Pb solubility, causing over 99 % of Pb precipitated from solution following oxalate < oxalate-phosphate < phosphate.

α-Hemihydrate calcium sulfate/n-hydroxyapatite combined with metformin promotes osteogenesis and .

This study aimed to examine the effects of loading different concentrations of metformin onto an α-hemihydrate calcium sulfate/nano-hydroxyapatite (α-CSH/nHA) composite. The material characteristics, biocompatibility, and bone formation were compared as functions of the metformin concentration. X-ray diffraction results indicated that the metformin loading had little influence on the phase composition of the composite.

The Effect of Risk Perception on Anxiety in Emerging Adulthood Under the Local Outbreak of COVID-19: A Conditional Process Analysis.

This study aims to explore the influence mechanism of COVID-19 risk perception on anxiety in emerging adulthood in the context of public health events of the second round of COVID-19 outbreaks and provide support for exploring the path of mental health after the normalization of the epidemic situation. An online questionnaire, combined with community social work, was used in this study, and data of 522 emerging adults were collected in February 2021. The Perceived Risk of COVID-19 pandemic scale (PRCPS), the generalized anxiety disorder 7-item (GAD-7) scale, the scale of affect balance, and the connor-davidson resilience scale (CD-RISC) were used to investigate.

Social support and well-being of adolescents in worst-stricken areas 10 years after Wenchuan Earthquake: A mediating role of resilience.

The purpose of this current study is to find the characteristics and influence mechanism of the perceived social support (PSS) and general well-being (GWB) of adolescents and to explore the mediating role of resilience on the relationship between PSS and GWB in the worst-stricken areas 10 years after the Wenchuan Earthquake. This study was conducted in two secondary schools in Beichuan (N = 1969) using the Perceived Social Support Scale, the Connor-Davidson Resilience Scale, and the General Well-Being Scale. Results showed that PSS of adolescents in the worst-stricken area significantly decreased compared to 10 years ago and their current PSS was lower than their peers' in developed cities.

Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes.

Angiogenesis plays a key role in the pathology of diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. Understanding the driving forces of endothelial cell migration and organization, as well as the time frame of these processes, can elucidate mechanisms of action of important pathological pathways. Herein, we have developed an organ-specific microfluidic platform recapitulating the in vivo angiogenic microenvironment by co-culturing mouse primary brain endothelial cells with brain pericytes in a three-dimensional (3D) collagen scaffold.

Social Support from Adult Children, Parent-Child Relationship, Emotion Regulation Strategy, and Depressive Symptoms Among Chinese Older Adults.

We examined the association between social support from adult children (SSAC) and depressive symptoms among Chinese older adults, as well as the moderated mediation mechanism with the parent-child relationship as a mediator and with emotion regulation strategies (cognitive reappraisal and expressive suppression) as moderators. With a cross-sectional design, 356 Chinese older adults completed our questionnaire survey. Results revealed the negative association between SSAC and depressive symptoms among Chinese older adults, and the parent-child relationship mediated this association.

A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells.

Microfluidic-based organ-on-a-chip assays with simultaneous coculture of multi-cell types have been widely utilized for basic research and drug development. Here we describe a novel method for a primary cell-based corneal microphysiological system which aims to recapitulate the basic functions of the cornea and to study topically applied ocular drug permeation. In this study, the protocols for isolating and cultivating primary corneal epithelial cells and endothelial cells from mouse inbred strain C57BL/6J were optimized, to allow for the development of a primary-cell based microfluidic 3D micro-engineered cornea.

Relationships of orientation discrimination threshold and visual acuity with macular lesions in age-related macular degeneration.

Purpose: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions.

Methods: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD.