Integrated bioinformatics analysis of nucleotide metabolism based molecular subtyping and biomarkers in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancers, continues to challenge treatment outcomes due to its heterogeneity and complex tumor microenvironment (TME). Dysregulation in nucleotide metabolism has been identified as a significant factor in tumorigenesis, suggesting its potential as a therapeutic target.

Methods: This study analyzed LUAD samples from The Cancer Genome Atlas (TCGA) using Non-negative Matrix Factorization (NMF) clustering, Weighted Correlation Network Analysis (WGCNA), and various machine learning techniques.

Digital economy development boosts urban resilience-evidence from China.

Focusing on the impact of the digital economy on urban resilience is beneficial to the sustainable development of cities. This paper empirically examines the impact of digital economic development on urban resilience and its mechanisms by measuring urban resilience and the level of urban digital economy with the entropy-weighted TOPSIS method using the data of 252 Chinese cities from 2011 to 2020. The findings show that digital economic development effectively promotes urban resilience at the 1% significance level, and this conclusion remains valid after a series of endogeneity and robustness tests.

Micro-perspective of listed companies in China: Digital development promotes the green transformation of the manufacturing industry.

In the context of the rapid development of the global digital economy, it is of great significance to explore the greening transformation of the manufacturing industry from the micro-perspective of enterprise digital development. This paper empirically examines the impact and mechanism of enterprise digital development on the greening transformation of the manufacturing industry using the 2010-2020 data of Chinese A-share listed companies in the manufacturing industry as a sample. The study shows that enterprise digital development can significantly promote the greening transformation of China's manufacturing industry, and this conclusion still holds after a series of robustness tests.

Overexpressed FAM111B degrades GSDMA to promote esophageal cancer tumorigenesis and cisplatin resistance.

Background: Chemotherapeutic agents such as cisplatin are commonly used in patients with clinically unresectable or recurrent esophageal cancer (ESCA). However, patients often develop resistance to cisplatin, which in turn leads to a poor prognosis. Studies have shown that FAM111B may be involved in the development of tumors as an oncogene or tumor suppressor gene.

High-performance thermoplastic starch/poly(butylene adipate-co-terephthalate) blends through synergistic plasticization of epoxidized soybean oil and glycerol.

Utilizing starch, an abundant polysaccharide, as the renewable filler to blend with poly(butylene adipate-co-terephthalate) (PBAT) is a feasible tactic to construct cost-effective and high-performance biodegradable materials. It's worth noting that the thermal processing properties of starch can be manipulated by its plasticized behavior. Herein, epoxidized soybean oil (ESO) and glycerol were used as the plasticizer for native corn starch and the plasticized starch was integrated with PBAT to manufacture starch-based biodegradable blend films.

Lysosome-Targeting Fluorescence Sensor for Sequential Detection and Imaging of Cu and Homocysteine in Living Cells.

A conjugated polymer-based fluorescence sensor, namely, PTNPy, was constructed on the basis of a polythiophene scaffold coupled with dimethylpyridylamine (DPA) groups in side chains for the consecutive detection and quantification of Cu and Hcy in a perfect aqueous medium. A dramatic fluorescence quenching of PTNPy by the addition of Cu was observed in Tris-HCl buffer solution (2 mM, pH 7.4), demonstrating a quick (<1 min) and highly selective response to Cu with a low limit of detection of 6.

Central Unit Fluorination of Non-Fullerene Acceptors Enables Highly Efficient Organic Solar Cells with Over 18 % Efficiency.

Halogenation of terminal of acceptors has been shown to give dramatic improvements in power conversion efficiencies (PCEs) of organic solar cells (OSCs). Similar significant results could be expected from the halogenation of the central units of state-of-the-art Y-series acceptors. Herein, a pair of acceptors, termed CH6 and CH4, featuring a conjugation-extended phenazine central unit with and without fluorination, have been synthesized.

Corporate Social Responsibility and Consumer Emotional Marketing in Big Data Era: A Mini Literature Review.

In the digital era, big data can strengthen the awareness of corporate social responsibility (CSR) and make CSR more transparent to consumers. While big data continues to deepen the business transformation of enterprises, it is also a process of constantly understanding consumption and public expectations. In this process, the cognitive structure of enterprises is constantly adjusted, no longer simply pursuing performance but constantly realizing the expectations of users and society in order to maintain performance.

Fractionation of technical lignin and its application on the lignin/poly-(butylene adipate-co-terephthalate) bio-composites.

Complex and heterogeneous structures of lignin impede its further conversion and valorization. Herein, three technical lignins (from softwood, hardwood, and grass) were fractionated with acetone solvent to reduce their structural heterogeneity, which were then blended with poly-(butylene adipate-co-terephthalate) (PBAT) to fabricate biodegradable bio-composites. Macromolecular structures of lignins and their effects on the properties of lignin/PBAT composites were thoroughly investigated.

The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC.

Clear cell renal cell carcinoma (ccRCC) accounts for 85% of all malignant renal tumors. Currently, the pathogenesis of ccRCC is not fully understood. Chromobox (CBX) family proteins are the major subunits of PcG complexes and are implicated in regulating mammalian development.

The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.

Bladder cancer is one of the most lethal cancers in the world. Despite the continuous development of medical technologies and therapeutic strategies, the overall survival rate of bladder cancer has not changed significantly. Targeted therapy is a new promising method for bladder cancer treatment.

Clinical Characterization of Mismatch Repair Gene-Deficient Metastatic Castration-Resistant Prostate Cancer.

Mismatch repair-deficient (dMMR) prostate cancer is rare and has not been well studied. We aimed to evaluate the clinical characterization of dMMR metastatic castration-resistant prostate cancer (mCRPC) patients. The MMR genes include MLH1, MLH3, MSH2, MSH6, PMS1, PMS2, and EPCAM, and were analyzed by targeted sequencing of plasma cell-free DNA samples.

Gene set based systematic analysis of prostate cancer and its subtypes.

A gene set based systematic analysis strategy is used to investigate prostate tumors and its subclusters with focuses on similarities and differences of biological functions. Dysregulation of methylation status, as well as RAS/RAF/ERK and PI3K-ATK signaling pathways, were found to be the most dramatic changes during prostate cancer tumorigenesis. Besides, neural and inflammation microenvironment is also significantly divergent between tumor and adjacent tissues.

The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis.

The relationship between metformin and prostate cancer (PCa) remains controversial. To clarify this association, the PubMed, Embase and Cochrane library databases were systematically searched from their inception dates to May 23, 2018, using the keywords "metformin" and "prostate cancer" to identify the related studies. The results included incidence, overall survival (OS), PCa-specific survival (CSS) and recurrence-free survival (RFS), which were measured as hazard ratios (HR) with a 95% confidence interval (95% CI) using Review Manager 5.

Impact of nano-CaCO3 -LDPE packaging on quality of fresh-cut sugarcane.

Background: In order to evaluate the effects of nano-CaCO3 -based low density polyethylene (nano-CaCO3 -LDPE) packaging on the quality of fresh-cut sugarcane, concentrations of O2 and CO2 within the packages, overall visual quality (OVQ), total bacterial count (TBC), yeast and mould count (YMC), reducing sugar content and total phenolic content, respiration, ethylene production, and the activities of phenylalanine ammonia-lyase (PAL), polyphenol oxidase (PPO), peroxidase (POD), acid invertase (AI) and neutral invertase (NI) were examined during storage at 10 °C for 5 days.

Results: The transmission rate of O2 and CO2 of the nano-CaCO3 -LDPE material was lower than that of LDPE, which lead to the more rapid formation of gas environment with low O2 and high CO2 concentration in the package. TBC and YMC counts of fresh-cut sugarcane were significantly retarded by nano-CaCO3 -LDPE packaging.