Polysaccharides from Sacha Inchi shell reduces renal fibrosis in mice by modulating the TGF-β1/Smad pathway and intestinal microbiota.

Renal fibrosis is a common pathway involved in the progression of various chronic kidney to end-stage diseases, posing a substantial global public health challenge in the search for effective and safe treatments. This study investigated the effects and mechanisms of sacha inchi shell polysaccharide (SISP) on renal fibrosis induced by a high-salt diet (HSD) in mice. By analysing kidney-related protein pathways and the structure of gut microbiota, we found that SISP significantly reduced urinary protein levels induced by a HSD from 41.

Recent progress in environmental applications of metal-organic frameworks.

Nanomaterials have aroused the interest of many researchers and become a research hotspot in recent years and metal-organic frameworks (MOFs) included in that are a class of new organic-inorganic hybrid porous materials formed through the self-assembly of organic ligands and inorganic metal ions. MOFs have been attracting increasing attention due to their structural diversification, large specific surface area, high porosity, inerratic pore space framework. These characteristics play their advantages in different fields and make some excellent achievements.