The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via mA RNA methylation-mediated TRAF1 expression.

The imbalance of vascular endothelial cell homeostasis is the key mechanism for the progression of many vascular diseases. RNA modification, particularly N-Methyladenosine (mA), plays important function in numerous biological processes. Nevertheless, the regulatory function of mA RNA methylation in endothelial dysfunction remains insufficiently characterized.