A Sophisticated Ratiometric Nuclear Medicine Imaging Strategy for Biological Microenvironment Abnormal Factor Detection.

Biological microenvironment detection is crucial for deciphering the mechanisms underlying malignant progression and predicting the treatment efficacy of diseases. Nevertheless, only very limited progress has been made toward non-invasive and quantitative detection of microenvironment abnormal factors, let alone with clinically compatible imaging modalities. Herein, a smart nuclear medicine probe is proposed, innovatively designed for quantitative visualization of glutathione (GSH) in vivo.