Clozapine boosting N/Cl co-doped carbon skeleton synergistically optimizing NaV(PO) with superior performance and excellent thermal stability.

Nowadays, the limited electronic conductivity and structural deterioration during battery cycling have hindered the widespread application of NaV(PO) (NVP). In response to these challenges, we advocate for a technique involving the application of carbon modifications to NVP to enhance its suitability as cathode material. This work involves the synthesis of N/Cl co-modified in situ carbon coatings derived from clozapine (CZP) through a facile hydrothermal route.

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection.

DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS-Cav1, SC-TM, and DS2.

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1.

The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat of SARS-CoV-1 and other sarbecoviruses, underscore the urgent need for effective strategies against their infection and transmission. This study highlights the discovery of nanobodies from immunized alpacas, which demonstrate exceptionally broad and potent neutralizing capabilities against the recently emerged and more divergent SARS-CoV-2 Omicron subvariants including JD.1.

Sc substituted NaV(PO) on N-doped porous carbon skeleton boosting high structural stability and superior electrochemical performance for full sodium ion batteries.

The poor structural stability and conductivity of NaV(PO) (NVP) have been serious limitations to its development. In this paper, Sc is selected to replace partial site of V which can enhance its ability to bond with oxygen, forming the ScO octahedral unit, resulting in improved structural stability and better kinetic properties for the NVP system. Moreover, due to the larger ionic radius of Sc compared to V, moderate Sc substitution can support the crystal framework as pillar ions and expand the migration channels for de-intercalation of Na, thus efficiently promoting ionic conductivity.

Enhanced performance of Sn-doped NaV(PO) with CNT integration for high-efficiency sodium-ion batteries.

The development of NaV(PO) (NVP) has been severely hindered by low conductivity and unstable crystal structure. A simultaneously optimized strategy of Na-rich and Sn substitution is proposed for the first time. SnX-NVP@CNTs with different doping gradients are successfully prepared by the facile sol-gel method.

Se-induced defective carbon nanotubes promoting superior kinetics and electrochemical performance in NaV(PO) for half and full Na ion cells.

NaV(PO) (NVP), with unique Na super ionic conductivity (NASICON) framework, has become an prospective cathode material. However, the low electronic conductivity and poor structural stability limit its further development. Currently, the optimized carbon nanotubes (CNTs) by selenium doping are utilized to modify NVP system for the first time.

Simultaneous Mn and Cl doping on NaV(PO) with high performance for full sodium-ion batteries.

Nowadays, the poor conductivity and unstable structure have become obstacles for the popularization of NaV(PO) (NVP). In the current work, a dual-modified MnCl-NVP composite doped with Mn and Cl is prepared by a facile sol-gel method. When Mn with a large ionic radius replaces small V, it can improve the stability of the NVP crystal structure.

Lamellar Keratoplasty Using Acellular Bioengineering Cornea (BioCorneaVet) for the Treatment of Feline Corneal Sequestrum: A Retrospective Study of 62 Eyes (2018-2021).

To retrospectively evaluate the effectiveness and outcome of lamellar keratoplasty using acellular bioengineering cornea (BioCorneaVet) for the treatment of feline corneal sequestrum (FCS). The medical records of cats diagnosed with FCS that underwent lamellar keratoplasty with BioCorneaVet between 2018 and 2021 with a minimum of 3 months of follow-up were reviewed. Follow-up examinations were performed weekly for 3 months, and then optical coherence tomography (OCT) examination was performed on select patients at 0, 3, 6, and 12 months post-operatively.

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection.

Background: Mycobacterium bovis (M. bovis) is the principal causative agent of bovine tuberculosis; however, it may also cause serious infection in human being. Type I IFN is a key factor in reducing viral multiplication and modulating host immune response against viral infection.

PP2Ac Modulates AMPK-Mediated Induction of Autophagy in -Infected Macrophages.

() is the causative agent of bovine tuberculosis in cattle population across the world. Human beings are at equal risk of developing tuberculosis beside a wide range of infections in animal species. Autophagic sequestration and degradation of intracellular pathogens is a major innate immune defense mechanism adopted by host cells for the control of intracellular infections.

Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.

Background: Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a potential anticancer agent in various types of human cancer. However, there are no reports evaluating the antitumor effects of ivermectin in canine mammary tumor.

Overexpression of matrix metalloproteinase-9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling.

Objectives: Matrix metalloproteinase 9 (MMP-9) has been frequently noticed in the breast cancers. In this study, we aim to investigate the associations of MMP-9 with the activation of transforming growth factor beta (TGF-β)/SMAD signalling and the malignancy of breast malignant tumour cells.

Materials And Methods: The distributions of MMP-9 and TGF-β in the tissues of canine breast cancers were screened by immunohistochemical assays.

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.

Nilotinib, a tyrosine kinase inhibitor, has been studied extensively in various tumor models; however, no information exists about the pharmacological action of nilotinib in bacterial infections. () and subspecies (MAP) are the etiological agents of bovine tuberculosis and Johne's disease, respectively. Although and MAP cause distinct tissue tropism, both of them infect, reside, and replicate in mononuclear phagocytic cells of the infected host.

Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.

Transcription factors play a significant role during the symptomatic onset and progression of prion diseases. We previously showed the immunomodulatory and nuclear factor of activated T cells' (NFAT) suppressive effects of an immunosuppressant, FK506, in the symptomatic stage and an antibiotic, minocycline, in the pre-symptomatic stage of prion infection in hamsters. Here we used for the first time, a combinatory FK506+minocycline treatment to test its transcriptional modulating effects in the symptomatic stage of prion infection.

Differences in pathogenicity of three animal isolates of Mycobacterium species in a mouse model.

Animal mycobacterioses are among the most important zoonoses worldwide. These are generally caused by either Mycobacterium tuberculosis (MTB), M. bovis (MBO) or M.

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.

Prion diseases are a group of infectious diseases characterized by multiple neuropathological changes, yet the mechanisms that preserve function and protect against prion-associated neurodegeneration are still unclear. We previously reported that the repressor element 1-silencing transcription factor (REST) alleviates neurotoxic prion peptide (PrP106-126)-induced toxicity in primary neurons. Here we confirmed the findings of the model in 263K infected hamsters, an model of prion diseases and further showed the relationships between REST and related signaling pathways.

Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.

Prion infections of the central nervous system (CNS) are characterized by initial reactive gliosis followed by overt neuronal death. Gliosis is likely to be caused initially by the deposition of misfolded, proteinase K-resistant, isoforms (termed PrP) of the normal cellular prion protein (PrP) in the brain. Proinflammatory cytokines and chemokines released by PrP-activated glia and stressed neurons may also contribute directly or indirectly to the disease development by enhancing gliosis and inducing neurotoxicity.

Defensins: The Case for Their Use against Mycobacterial Infections.

Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial cells. All three defensin types (-, -, and -defensins) have antibacterial activities, mainly through bacterial membrane permeabilization.

A perfusion culture system using a stirred ceramic membrane reactor for hyperproduction of IgG2a monoclonal antibody by hybridoma cells.

A novel perfusion culture system for efficient production of IgG2a monoclonal antibody (mAb) by hybridoma cells was developed. A ceramic membrane module was constructed and used as a cell retention device installed in a conventional stirred-tank reactor during the perfusion culture. Furthermore, the significance of the control strategy of perfusion rate (volume of fresh medium/working volume of reactor/day, vvd) was investigated.