PPZ1-TORC1 pathway mediates ferroptosis and antifungal resistance in Candida albicans.

Candida albicans (C. albicans), a common fungal pathogen, is responsible for infections such as oral candidiasis. Given the widespread misuse of antifungal medications and the increasing resistance, it is critical to explore new strategies to eradicate C.

Autophagy regulation of and on biofilm formation and antifungal resistance in .

Autophagy is a highly conserved catabolic pathway that is vital for cells; however, the effects of autophagy on the biofilm formation and antifungal resistance of are still unknown. In this study, the potential molecular mechanisms of autophagy in biofilm formation and antifungal resistance were investigated. It was found that 3536 genes were differentially expressed between biofilm and planktonic gene expression and autophagy activity were higher in biofilm than in planktonic .