METTL3-induced UCK2 mA hypermethylation promotes melanoma cancer cell metastasis via the WNT/β-catenin pathway.

Background: Melanoma is a highly aggressive, malignant skin tumor with a statistically high mortality rate. N6-methyladenosine (mA) modification is involved in a variety of biological processes, including tumorigenesis. mA modifications regulate the fate and functions of RNA, such as mRNA stability, nuclear processing, transport, localization, translation, primary microRNA (miRNA) processing, and RNA-protein interactions.