Serum autoantibody-based biomarkers for prognosis in early-stage lung cancer patients with surgical resection.

Background: Lung cancer is the cancer with the highest morbidity and mortality in the world. With the increasing diagnosis rate of patients with early-stage lung cancer, surgery treatment becomes an option for more patients. However, there is a lack of effective indicators to assess the risk of recurrence after lung cancer surgery.

H3K4me3 Genome-Wide Distribution and Transcriptional Regulation of Transposable Elements by RNA Pol2 Deposition.

Zygotic genome activation (ZGA) is critical for early embryo development and is meticulously regulated by epigenetic modifications. H3K4me3 is a transcription-permissive histone mark preferentially found at promoters, but its distribution across genome features remains incompletely understood. In this study, we investigated the genome-wide enrichment of H3K4me3 during early embryo development and embryonic stem cells (ESCs) in both sheep and mice.

Sexual dimorphism in aortic aneurysm: A review of the contributions of sex hormones and sex chromosomes.

Aortic aneurysm is a common cardiovascular disease. Over time, the disease damages the structural and functional integrity of the aorta, causing it to abnormally expand and potentially rupture, which can be fatal. Sex differences are evident in the disease, with men experiencing an earlier onset and higher incidence.

Enantioselective Toxicity of Ibuprofen to Earthworms: Unraveling the Effect and Mechanism on Enhanced Toxicity of -Ibuprofen Over -Ibuprofen.

With the global implementation of wastewater reuse, accurately assessing the soil ecological risk of chiral pollutants from wastewater necessitates a comprehensive understanding of their enantioselective toxicity to soil animals. Ibuprofen (IBU) is the most prevalent chiral pharmaceutical in municipal wastewater. However, its enantioselective toxicity toward soil animals and the underlying mechanism remain largely unknown.

Isolation and characterization of a triplet nitrene.

Nitrene radical compounds are short-lived intermediates in a variety of nitrogen-involved transformations. They feature either a singlet or a triplet ground state, depending on the electronic properties of the substituents. Triplet nitrenes are highly reactive and their isolation in the condensed phase under ambient conditions is challenging.

Enhancement of Selective Catalytic Oxidation of Lignin β-O-4 Bond via Orbital Modulation and Surface Lattice Reconstruction.

The orbital modulation and surface lattice reconstruction represent an effective strategy to regulate the interaction between catalyst interface sites and intermediates, thereby enhancing catalytic activity and selectivity. In this study, the crystal surface of Au-K/CeO catalyst can undergo reversible transformation by tuning the coordination environment of Ce, which enables the activation of the C-H bond and the oxidative cleavage of the C and C-C bonds, leading to the cleavage of 2-phenoxy-1-phenylethanol. The t orbitals of Au 5d hybridize with the 2p orbitals of lattice oxygen in CeO via π-coordination, modulating the coordination environment of Ce 4 f and reconstructing the lattice oxygen in the CeO framework, as well as increasing the oxygen vacancies.

Imaging-based terahertz pixelated metamaterials for molecular fingerprint sensing.

With the rapid development of terahertz-enabled devices, the study of miniaturized and integrated systems has attracted significant attention. We experimentally demonstrate an imaging-based pixelated metamaterial for detecting terahertz molecular fingerprints related to intermolecular vibrations and large-amplitude intramolecular modes, including chemical identification and compositional analysis. The compact THz sensor consists of a 4 × 4 pixelated filter-detector array with transmission resonances tuned to discrete frequencies.

Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults: 30 years' overview and forecasted trends.

Background: Hepatobiliary and pancreatic (HBP) cancers impose a considerable burden on young populations (aged 15 to 49 years), resulting in a substantial number of new cases and fatalities each year. In young populations, the HBP cancers shows extensive variance worldwide and the updated data in China is lacking.

Aim: To investigate the current status, trends, projections, and underlying risk factors of HBP cancers among young populations in China.

Photocatalytic Reforming of Ethanol in the Liquid Phase Using a Ternary Composite of Rh/TiO/g-CN as a Catalyst.

Photocatalytic reforming of ethanol provides an effective way to produce hydrogen energy using natural and nontoxic ethanol as raw material. Developing highly efficient catalysts is central to this field. Although traditional semiconductor/metal heterostructures (e.

Do regional tax incentive policies improve productivity?

The difficulty in transforming old industrial areas constitutes a significant factor contributing to regional development imbalances. Can regional tax incentives, as a crucial component of regional policies, polish the "rust belt" regions? This study leverages the inaugural Value-Added Tax (VAT) reform in China as an opportunity to explore the potential of regional tax incentives in achieving sustainable development in traditional industrial areas. Drawing upon a comprehensive industrial enterprise database, we employ a Propensity Score Matching-Difference in Differences (PSM-DID) approach to examine the efficacy of these tax incentives.

Acousto-Drag Photovoltaic Effect by Piezoelectric Integration of Two-Dimensional Semiconductors.

Light-to-electricity conversion is crucial for energy harvesting and photodetection, requiring efficient electron-hole pair separation to prevent recombination. Traditional junction-based mechanisms using built-in electric fields fail in nonbarrier regions. Homogeneous material harvesting under a photovoltaic effect is appealing but is only realized in noncentrosymmetric systems via a bulk photovoltaic effect.

Impact of adsorption on thermal conductivity dynamics of adsorbate and adsorbent: Molecular dynamics study of methane and Cu-BTC.

Understanding changes in thermodynamic and transport properties during adsorption is crucial for the thermal management of metal-organic frameworks, which also imposes significant challenges for improved performance and energy density of adsorption system. Because of phase transitions in the intermolecular interactions involved in the adsorption phenomena, transport properties including the thermal conductivity exhibit interesting behaviors, yet fully understood. This study employs detailed molecular dynamics simulations to replicate the methane/Cu-BTC adsorption phenomenon for the evaluation of their thermal conductivities across different pressures and temperatures.

Ultrasonic-driven degradation of organic pollutants using piezoelectric catalysts WS/BiWO heterojunction composites.

Water pollution has been made worse by the widespread use of organic dyes and their discharge, which has coincided with the industry's rapid development. Piezoelectric catalysis, as an effective wastewater purification method with promising applications, can enhance the catalyst activity by collecting tiny vibrations in nature and is not limited by sunlight. In this work, we designed and synthesized intriguing WS/BiWO heterojunction nanocomposites, investigated their shape, structure, and piezoelectric characteristics using a range of characterization techniques, and used ultrasound to accelerate the organic dye Rhodamine B (RhB) degradation in wastewater.

Effects of Alumina Bubble Addition on the Properties of Corundum-Spinel Castables Containing CrO.

Purging plugs made of corundum-spinel castables containing CrO have been widely utilized in secondary refining process. However, their poor thermal shock resistance has greatly limited the improvement of their service life. Aiming to enhance their properties, we introduced alumina bubbles (ABs) to corundum-spinel castables, and the effects of the AB addition on the properties of the castables are studied in this manuscript.

Therapeutic efficacy of drilling drainage combined with intraoperative middle meningeal artery occlusion in the management of chronic subdural hematoma: a clinical study.

Background: The bone holes in the skull during surgical drainage were accurately located at the site of the MMA. The MMA was severed, and the hematoma was removed intraoperatively; furthermore, surgical drainage removed the pathogenic factors of CSDH. This study aimed to describe and compare the results of the new treatment with those of traditional surgical drainage, and to investigate the relevance of this approach.

Hyaluronic acid-poly(glyceryl)10-stearate nanoemulsion for co-delivery of fish oil and resveratrol: Enhancing bioaccessibility and antioxidant potency.

Hyaluronic acid (HA), an endogenous polysaccharide comprising alternating D-glucuronic acid and N-acetylglucosamine units, is renowned for its high hydrophilicity, biocompatibility, and biodegradability. These attributes have rendered HA invaluable across medical and drug delivery fields. HA can be altered through physical, chemical, or enzymatic methods to improve the properties of the modified substances.

Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics.

Nucleic acid aptamers are oligonucleotide chains with molecular recognition properties. Compared with antibodies, aptamers show advantages given that they are readily produced chemical synthesis and elicit minimal immunogenicity in biomedicine applications. Notably, aptamer-encoded nucleic acid assemblies further improve the binding affinity of aptamers with the targets due to their multivalent synergistic interactions.

Raman Monitoring of the Electro-Optical Synergy-Induced Enhancements in Carbon-Bromine Bond Cleavage, Reaction Rate, and Product Selectivity of -Bromothiophenol.

Electro-optical synergy has recently been targeted to improve the separation of hot carriers and thereby further improve the efficiency of plasmon-mediated chemical reactions (PMCRs). However, the electro-optical synergy in PMCRs needs to be more deeply understood, and its contribution to bond dissociation and product selectivity needs to be clarified. Herein, the electro-optical synergy in plasmon-mediated reduction of -bromothiophenol (PBTP) was studied on a plasmonic nanostructured silver electrode using in situ Raman spectroscopy and theoretical calculations.

Actuation mechanism of a nanoscale drilling rig based on nested carbon nanotubes.

With the increasing emphasis on health and the continuous improvement of medical standards, more and more micro/nano devices are being used in the medical field. However, the existing micro/nano devices cannot effectively solve various problems encountered in medical processes and achieve specific therapeutic effects. Based on this, this article designs a new type of nanoscale drilling rig.

Selective Capture and Manipulation of DNA through Double Charged Nanopores.

In the past few decades, nanometer-scale pores have been employed as powerful tools for sensing biological molecules. Owing to its unique structure and properties, solid-state nanopores provide interesting opportunities for the development of DNA sequencing technology. Controlling DNA translocation in nanopores is an important means of improving the accuracy of sequencing.

An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders.

The adverse use of alcohol is a serious global public health problem. Maternal alcohol consumption during pregnancy usually causes prenatal alcohol exposure (PAE) in the developing fetus, leading to a spectrum of disorders known as fetal alcohol spectrum disorders (FASD) and even fetal alcohol syndrome (FAS) throughout the lifelong sufferers. The prevalence of FASD is approximately 7.

Rare-Earth Metal Complexes Supported by A Tridentate Amidinate Ligand: Synthesis, Characterization, and Catalytic Comparison in Isoprene Polymerization.

To systematically investigate the dependence of the initiating group and metal size on polymerization performance, a family of rare-earth metal bis(alkyl)/bis(benzyl)/bis(amide) complexes supported by a monoanionic tridentate amidinate ligand [(2,6-PrCH)NC(Ph)N(CH-2-OMe] () were synthesized and well-characterized. Treatment of rare-earth metal tris(alkyl)/tris(benzyl)/tris(amide) complexes Y(CHCHNMe-) or Y(CHSiMe)(THF) or Ln[N(SiHMe)](THF) (Ln = Sc, x = 1; Ln = Y, La, Sm, Lu, x = 2) with 1 equiv of gave the corresponding mono(amidinate) rare-earth metal bis(alkyl)/bis(benzyl)/bis(amide) complexes [(2,6-PrCH)NC(Ph)N(CH-2-OMe)]Y(CHCHNMe-) (), [(2,6-PrCH)NC(Ph)N(CH-2-OMe)]Y(CHSiMe)(THF) (), and [(2,6-PrCH)NC(Ph)N(CH-2-OMe)]Ln[N(SiHMe)](THF) (Ln = Y, = 1 (); Ln = La, = 1 (); Ln = Sc, = 0 (); Ln = Lu, = 0 (); Ln = Sm, = 0 ()) in good isolated yields. These complexes were characterized by elemental analysis, NMR spectroscopy, and single-crystal X-ray diffraction.