Publications by authors named "Hao-tang Ren"
Article Synopsis
- Acute-on-chronic liver failure (ACLF) and decompensated cirrhosis (DC) are severe complications of chronic hepatitis B virus (HBV) infection, marked by metabolic disturbances in the liver and beyond.
- A study analyzed serum samples and liver tissues from patients with HBV-ACLF, HBV-DC, and control groups to explore metabolic changes, highlighting impairments in energy, amino acid, and pyrimidine metabolism specific to ACLF/DC.
- The research found that both conditions share similar abnormal serum metabolite profiles linked to inflammation and metabolic dysfunction, with unique markers for each, suggesting a connection between liver pathology and systemic inflammatory response.
Article Synopsis
- Acute-on-chronic liver disease (AoCLD) is a major cause of hospitalization in hepatology, prompting a study to better understand its characteristics for diagnosis and prognosis.
- A total of 3,375 patients were analyzed, highlighting that liver cirrhosis acute decompensation (LC-AD) is the most common type, with hepatitis B virus (HBV) being the leading cause of chronic liver disease.
- The study revealed high mortality rates associated with AoCLD subtypes, emphasizing that bacterial infections are significant precipitating factors and that timely medical intervention is crucial for improving patient outcomes.
Prevalence and Clinical Significance of Portal Vein Thrombosis in Patients With Cirrhosis and Acute Decompensation.
Clin Gastroenterol Hepatol
October 2020
Article Synopsis
- Portal vein thrombosis (PVT) is a serious issue in cirrhosis patients and is more common in those experiencing acute decompensation (AD), with a prevalence of 9.36% compared to 5.24% in those without AD.
- Recent PVT was found in 63.37% of patients with cirrhosis and AD, and these patients also had higher rates of variceal bleeding and elevated D-dimer levels.
- Despite the higher incidence of bleeding and complications, the one-year mortality rate was similar between patients with and without PVT, highlighting the need for preventive measures and regular screenings in vulnerable cirrhosis patients.
Objective: To investigate the effect of partial internal sphincter myomectomy on transanal one-stage pull-through operation for Hirschsprung disease (HD).
Methods: A prospective group of 153 pediatric patients with HD in Guangdong Dongguan People's Hospital between 2003-2012 were enrolled, who underwent transanal one-stage pull-through operation. Children were divided into partial resection group (77 cases) undergoing partial internal sphincter myomectomy and simple incision group (76 cases) undergoing simply internal sphincter dissection, respectively.