Publications by authors named "Hao-jun Shi"
Article Synopsis
- The study investigated the relationship between sarcopenia (SP) and osteoarthritis (OA) using Mendelian randomization (MR) to clarify potential genetic connections.
- It analyzed large genetic data sets from the UK Biobank and the Genetics of Osteoarthritis Consortium, focusing on traits like appendicular lean mass and grip strength, alongside various subsets of OA.
- Results indicated that SP traits were causally linked to increased OA risk, while OA also adversely affected SP traits, suggesting a complex relationship between these conditions.
Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy.
World J Gastroenterol
January 2017
Aim: To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival.
Methods: Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected before and after surgery, and during the follow-up were evaluated.
Aim: To identify predictors for synchronous liver metastasis from resectable pancreatic ductal adenocarcinoma (PDAC) and assess unresectability of synchronous liver metastasis.
Methods: Retrospective records of PDAC patients with synchronous liver metastasis who underwent simultaneous resections of primary PDAC and synchronous liver metastasis, or palliative surgical bypass, were collected from 2007 to 2015. A series of pre-operative clinical parameters, including tumor markers and inflammation-based indices, were analyzed by logistic regression to figure out predictive factors and assess unresectability of synchronous liver metastasis.
[Association between delayed enhancement on cardiac magnetic resonance imaging and arrhythmia in patients with hypertrophic cardiomyopathy].
Zhonghua Xin Xue Guan Bing Za Zhi
September 2010
Objective: to observe the association between myocardial fibrosis, detected by delayed-enhancement (DE) cardiac magnetic resonance imaging (MRI) and arrhythmia in patients with hypertrophic cardiomyopathy (HCM).
Methods: forty-eight untreated HCM patients who underwent Cine MR, DE-MRI, 24 h ambulatory Holter electrocardiogram and ECG examinations were recruited. Extent of myocardial fibrosis (fibrosis mass/total LV mass) was assessed using DE imaging.
Objective: To explore the effect of hypoxia inducible factor-1 alpha (HIF-1 alpha) gene on the expression of vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (hRPE) cells under hypoxia conditions by using small hairpin loop RNA (shRNA) to silence HIF-1 alpha.
Methods: CoCl(2) (150 micromol/L) was used to simulate the hypoxia environment for hRPE cells. After choosing a target site of HIF-1 alpha mRNA, shRNA was designed and synthesized by this target site.