Publications by authors named "Hao-Yun Tang"
NIR C-Myc Pu22 G-quadruplex probe as a photosensitizer for bioimaging and antitumor study.
Spectrochim Acta A Mol Biomol Spectrosc
June 2023
Despite the fact that C-Myc G-quadruplex in the oncogene promoter regions is one of the crucial targets of antitumor drugs, the selectivities and proliferation inhibitions of its probes towards tumor cells remain a big challenge. Until now, no effective C-Myc G-quadruplex probes have been reported as a photosensitizer to increase their antitumor activities. Here, the first NIR C-Myc G-quadruplex probe PDS-SQ has been designed, comprising a G-quadruplex binder PDS and a squaraine dye SQ as a photosensitizer.
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- Five new cationic sulfonamide-substituted dibenzothiazole squaraines (SQ-D1 to SQ-D5) were synthesized based on zwitterionic dibenzothiazole squaraine SQ.
- Among them, SQ-D2 emerged as the most effective photosensitizer due to its rigid structure and strong electron-withdrawing -CN group, demonstrating superior ROS generation, photostability, and photo-cytotoxicity.
- In animal studies, SQ-D2 showed effective tumor retention, easy removal, and impressive PDT efficacy at low doses, outperforming some clinically approved photosensitizers for treating human breast cancer, indicating its potential for future cancer therapies.