Publications by authors named "Hao-Yuan Hong"
Article Synopsis
- Diffuse large B-cell lymphoma (DLBCL) has high mortality, and this study focuses on the role of small nucleolar RNAs (snoRNAs) as potential tumor-specific markers with little prior research in this area.
- A specific snoRNA-based signature was constructed from survival-related snoRNAs, allowing researchers to categorize DLBCL patients into high-risk and low-risk groups based on prognosis, using a proposed nomogram for clinical application.
- The study identified a three-snoRNA signature (including SNORD1A) linked to poor survival outcomes, revealing insights into biological mechanisms through co-expressed genes connected to ribosome and mitochondrial functions, and highlighted key mutations in DLBCL patients.
Rationale: Extranodal nature killer/T-cell lymphoma (ENKTL) failing in asparaginase-containing treatments is fatal, it has a higher mortality rate when accompanied by secondary hemophagocytic lymphohistiocytosis (HLH). The study reported 2 ENKTL-related HLH patients.
Patient Concerns: Patient 1 visited for nasal congestion and runny nose for 6 months then got a fever and serious myelosuppression after P-GEP (pegaspargase, gemcitabine, etoposide, and methylprednisolone) chemotherapy.