Publications by authors named "Hao-Yu Tian"
Article Synopsis
- - The study investigates how inflammatory factors influence the development of cerebral small vessel disease (CSVD) using Mendelian randomization (MR) and summary-data-based MR (SMR) to analyze the relationship between inflammation and CSVD markers while considering gene expression and DNA methylation effects.
- - Researchers utilized public databases and genome-wide studies to gather data on inflammatory factors and CSVD outcomes, applying various MR methods and sensitivity analyses to validate their findings on causal relationships.
- - Results indicated that increased levels of specific inflammatory factors (like TRAIL and IL-1RL2) are associated with a higher risk of small vessel stroke, while others (like E-selectin) might reduce the risk of certain CSVD markers, highlighting the complexity of these
Ethnopharmacological Relevance: Huzhangqingmaiyin (HZQMY) is a Chinese medicine formula used to treat small vessel disease, but the mechanism is unclear.
Aim Of The Study: This study aimed to reveal the protective effects of HZQMY on human brain microvascular endothelial cells (HBMECs) and explore the potential targets and mechanistic pathways using network pharmacology on treating cerebral small vessel disease (CSVD).
Materials And Methods: HBMECs were cultured in vitro and an endothelial cell injury model was constructed by hypoxia for 12 h followed by reoxygenation for 8 h (H/R).
A regioselective metal-free sulfenylation of imidazoheterocycles with heterocyclic thiols or thiones has been achieved using a cross-dehydrogenative coupling method in water. In addition, the procedure has several advantages including green solvents, free of foul-smelling sulfur sources, and mild conditions, thus providing considerable application potential in the pharmaceutical industry.
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