Design, synthesis and activity evaluation of usnic acid monoesterification derivatives.

A new series of usnic acid (UA) monoesterified derivatives were designed and synthesised using UA () as starting material. The structural characterisation of all compounds was elucidated using H-NMR and C-NMR spectral data. studies demonstrated thatmost UA derivatives exhibited higher inhibitory activity against and .

A Review on the Phytochemistry and Pharmacology of the Genus Sterculia.

The Sterculia genus is comprised of approximately 300 species, which have been widely used as traditional medicines to treat inflammation, snake bites, gastrointestinal diseases, skin diseases, microbial infections and many other diseases. To gain a comprehensive understanding of the therapeutic potential of Sterculia plants, an extensive literature search was conducted in CNKI, Bing, Wanfang Database, Springer Database, Elsevier Database, Google Scholar, Baidu Scholar, PubMed, and other similar websites from January 1971 to March 2024. The research indicated that Sterculia species predominantly contain flavonoids, terpenoids, phenylpropanoids, fatty acids, alkaloids and other chemical components.

Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Vain.

Lichens are important sources of versatile bioactive compounds. Two new dibenzofurans , a multi-substituted single benzene ring , and two organic acid compounds along with 25 known compounds were isolated from the lichen Vain. Their structures were identified by physicochemical properties and spectral analyses.

Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells.

Siomycin A is a type of thiopeptide antibiotic that is isolated from the fermentation products of an endophytic actinomycin, which is derived from the medicinal plant . The present study investigated whether siomycin A has antitumor effects on a variety of cell lines. A Cell Counting Kit-8 assay was performed to detect the effects of siomycin A on cell viability; morphological changes in the MiaPaCa-2 cell line were analyzed using an inverted phase contrast microscope.

One new and seven known triterpene glycosides from the aerial parts of .

One new triterpene glycoside, asiaticoside I (), along with seven known ones (-), were isolated from the aerial parts of (Turcz.) Maxim. The structure of was elucidated on the basis of extensive spectroscopic methods including 1D-NMR, 2D-NMR and MS data.

LncRNA ANRIL affects the sensitivity of ovarian cancer to cisplatin via regulation of let-7a/HMGA2 axis.

This paper tried to explore ANRIL expression in ovarian cancer and how it affects cisplatin-sensitivity of ovarian cancer cells via regulation of let-7a/high-mobility group protein A2 (HMGA2) axis. qRT-PCR was used to detect ANRIL and let-7a levels in ovarian cancer tissues and cell lines (SKOV3 and SKOV3/DDP). Then cells were randomly assigned into Blank, negative control siRNA, ANRIL siRNA, let-7a inhibitor, and ANRIL siRNA+let-7a-inhibitor groups.

[Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis].

In recent years, owing to the abuse of antibiotics, the widespread of resistant bacterial strains became a serious threat to public health. This status demands development of new antibacterial agents with novel mechanisms of action. The reason for the limited new antibacterials is the small number of effective therapeutic targets, which cannot meet the current needs for the multiple drug-resistant treatment.