Publications by authors named "Hao-Yang Shen"
Article Synopsis
- Histone deacetylase (HDAC) plays a critical role in regulating gene expression, and its inhibitors (HDACi) have shown promise in enhancing antitumor immunity, particularly in lung adenocarcinoma (LUAD) where their exact effects remain poorly understood.
- The study utilized mouse models to investigate the therapeutic impact and mechanisms of the pan-HDAC inhibitor vorinostat (SAHA), which was found to boost CD8+ T-cell infiltration and activity by suppressing the FGL1 ligand associated with LAG-3.
- The combination of SAHA with anti-LAG-3 therapy demonstrated the potential for reduced tumor growth and increased T-cell effectiveness, revealing a novel pathway involving the HDAC1/JAK1
Phthalate acid esters (PAEs) are one of the most widely used plasticizers globally, extensively employed in various decoration materials. However, studies on the impact of these materials on indoor environmental PAE pollution and their effects on human health are limited. In this study, forty dust samples were collected from four types of stores specializing in decoration materials (flooring, furniture boards, wall coverings, and household articles).
View Article and Find Full Text PDFDue to the abusive use of antibiotics, bacterial resistance has become a global problem and poses severe threats to aquaculture. The drug-resistant diseases caused by Vibrio alginolyticus have caused significant economic losses to cultured marine fish. Fructus schisandrae is used to treat inflammatory diseases in China and Japan.
View Article and Find Full Text PDF