-Benzylhydroxylamine as a novel synthetic block in "C1N1" embedding reaction α-C(sp)-H activation strategy.

A novel process using -benzylhydroxylamine hydrochloride as a "C1N1 synthon" in [2+2+1] cyclization for the construction of 1,2,5-trisubstituted imidazoles has been described for the first time. The key to realizing this process lies in capturing arylamines by generated novel acyl ketonitrone intermediates. Subsequent tautomerization activates the α-C(sp)-H of -benzylhydroxylamines, and thus breaks through its inherent reaction mode and achieves , α-C site-selective cyclization.

LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer.

Leukemia inhibitory factor receptor (LIFR) has been documented as a cancer promoter and to be present at high levels in various types of tumor tissues. In our search for molecules prognostic of colorectal cancer (CRC), we found high levels of LIFR in CRC tissue samples. Further analyses revealed that LIFR was indeed prognostic of CRC patient survival, and was associated with tumor size, lymphatic metastasis and stages.