Synchronous carcinomas of the esophagus: Influence of prognosis and staging.

Objective: Synchronous carcinomas of the esophagus (SCEs), occurring at multiple locations in the esophagus or the esophagogastric junction, are uncommon. In this study, we retrospectively analyzed patients with SCEs, focusing on the types of SCEs and their influence on staging and prognosis.

Methods: Data of patients treated surgically for esophageal carcinoma between January 2009 and January 2016 were retrieved from the database in the thoracic surgery department of our hospital.

Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice.

Objective: The low number of oligodendrocytes (OLs) in the hippocampus of patients with schizophrenia suggests that hippocampal demyelination is changed in this condition. Sox10 is expressed throughout OL development. The effect of Sox10 on myelin regeneration is unknown.

NEP1-40 alleviates behavioral phenotypes and promote oligodendrocyte progenitor cell differentiation in the hippocampus of cuprizone-induced demyelination mouse model.

Background: Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role in poor OPCs differentiation in the mouse model of demyelinating disease.