Publications by authors named "Hao-Wen Cui"
J Orthop Translat
July 2021
Article Synopsis
- Low back pain is a major global disability, largely due to intervertebral disc degeneration (IVDD), and this study focuses on the role of miR-133a-5p and FBXO6 in regulating IVDD.
- The investigation involved various methods, including gene expression assays and cell analysis, revealing that silencing FBXO6 leads to changes that promote NP cell degeneration, while miR-133a-5p inhibits FBXO6 expression and may exacerbate IVDD.
- Findings indicate that miR-133a-5p is upregulated in IVDD, and its inactivation can mitigate the degeneration process induced by FBXO6 silencing, implicating the NF-κB
