A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis.

Photoactivable chemotherapy (PACT) using metallic complexes provides spatiotemporal selectivity over drug activation for targeted anticancer therapy. However, the poor absorption in near-infrared (NIR) light region of most metallic complexes renders tissue penetration challenging. Herein, an NIR light triggered dinuclear photoactivable Ru(II) complex (Ru2) is presented and the antitumor mechanism is comprehensively investigated.

Serum microRNA profiles as diagnostic biomarkers for HBV-positive hepatocellular carcinoma.

Background & Aims: The discovery of effective and reliable biomarkers to detect hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) at an early stage may improve the survival of HCC. The aim of this study was to establish serum microRNA (miRNA) profiles as diagnostic biomarkers for HBV-positive HCC.

Methods: We used deep sequencing to screen serum miRNAs in a discovery cohort (n=100).

Serum microRNA profiles as prognostic biomarkers for HBV-positive hepatocellular carcinoma.

To establish serum microRNA profiles as prognostic biomarkers in hepatocellular carcinoma patients (HCCs), we used deep sequencing to screen serum microRNAs in a discovery set .Twelve up-regulated serum miRNAs were selected for qPCR analysis in a training set. MiR-192-5p and miR-29a-3p were identified and associated with HCC prognosis.

[Expression and clinical significance of PDGFRalpha and PDGFRbeta in colorectal cancer].

Background & Objective: Platelet-derived growth factor receptor-alpha (PDGFRalpha) and -beta (PDGFRbeta) play important roles in the invasion and metastasis of solid tumors. However, their correlations to colorectal cancer have seldom been reported. This study was to detect the expression of PDGFRalpha and PDGFRbeta in colorectal cancer, and investigate their clinical significance.