Th1 cell immune response in infection with anti-interferon-γ autoantibody syndrome.

Anti-interferon-γ autoantibody (AIGA) syndrome may be the basis of disseminated infection in human immunodeficiency virus (HIV)-negative adults. However, the pathogenesis of Th1 cell immunity in infection with AIGA syndrome is unknown. A multicenter study of HIV-negative individuals with infection was conducted between September 2018 and September 2020 in Guangdong and Guangxi, China.

Time-dependent haemoperfusion after acute paraquat poisoning.

Early haemoperfusion (HP) therapy has been found to be very effective in acute paraquat (PQ) poisoning, but the effective rescue window is still uncertain. Demographic data and the type of therapies administered of 621 patients were included as confounding factors in this retrospective study. After receiver operating characteristic curve analysis and intra-group/subgroup analysis, the initiation of glucocorticoid therapy within 3 hrs of exposure with a second treatment given <21 hrs after exposure, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure and six other variables were used in a multiple analysis.