Remineralization and bacterial inhibition of early enamel caries surfaces by carboxymethyl chitosan lysozyme nanogels loaded with antibacterial drugs.

Objective: This study aimed to develop dual-functional CMC-LYZ-ACP nanogels. Three different antibacterial substances, tea polyphenols (TPs), silver nitrate (AgNO), and chlorhexidine (CHX) are then combined to form three dual-functional CMC-LYZ-ACP nanogels for remineralization and antibacterial purposes.

Methods: An in vitro model of Streptococcus mutans biofilm was established to analyze the inhibitory effect of the antibacterial-remineralizing dual-functional nanogels on the biofilm.