Publications by authors named "Hao-Ran Guo"
Article Synopsis
- Depressive disorders are a significant global issue linked to inflammation, particularly increased after the COVID-19 pandemic, with the JAK-STAT signaling pathway not yet fully explored in this context.
- A recent analysis suggests that the JAK inhibitor tofacitinib may have potential beyond immune diseases by possibly preventing mood disorders.
- Research indicates that the JAK-STAT pathway is activated in depressive mouse models, leading to inflammation and synaptic issues, but tofacitinib shows promise in reversing these effects, highlighting its potential for treating depression.
A Gram-stain-negative, aerobic, motile and rod-shaped bacterium, the color of the bacterial colony ranges from light yellow to yellow, designated YC-2023-2T, was isolated from sediment sample of Yuncheng salt lake. Growth occurred at 15-45℃ (optimum 37℃), pH 6.0-9.
View Article and Find Full Text PDFDuring arbuscular mycorrhizal (AM) symbiosis, plant innate immunity is modulated to a prime state to allow for fungal colonization. The underlying mechanisms remain to be further explored. In this study, two rice genes encoding LysM extracellular (LysMe) proteins were investigated.
View Article and Find Full Text PDFDiabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon is unclear. In our study, we found that anxiety induces a region-specific reduction in AMPK activity in the medial prefrontal cortex (mPFC). Concurrently, transgenic mice with brain-specific AMPK knockout displayed abnormal anxiety-like behaviors.
View Article and Find Full Text PDFThe scientific basis of acupuncture on mesenchymal stem cells (MSCs) for treating ischemic stroke (IS) is discussed. MSCs transplantation has great potential for the treatment of tissue damage caused by early stage inflammatory cascade reactions of IS, but its actual transformation is limited by various factors. How to improve the homing efficiency of MSCs is the primary issue to enhance its efficacy.
View Article and Find Full Text PDF[Expression and Clinical Significance of CAS in Acute Myeloid Leukemia Patients].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2022
Objective: To explore the expression of cellular apoptosis susceptibility protein （CAS） in acute myeloid leukemia （AML） and its correlation with clinical characteristics.
Methods: The expression of CAS in bone marrow tissue of 54 patients with AML and 24 patients with non-hematological malignant diseases was detected by Western blot and immune-histochemical method, and compared between AML group and control group. Also the relationship of CAS expression in AML and sex, age, WBC count, Hb, platelet count, bone marrow blast cell ratio, ki-67 index, cytogenetic and molecular biological prognostic risk stratification, extramedullary infiltration and other clinical characteristics was analyzed.
Article Synopsis
- The study investigates the impact of high atmospheric nitrogen deposition on soil nitrogen levels and the biogeochemical cycle in forests, focusing on the Beijing-Tianjin-Hebei region of China.
- It finds that while these forests have higher levels of bioavailable nitrogen, they exhibit lower rates of nitrogen mineralization and nitrification compared to other global forests.
- The research concludes that increased nitrogen deposition enhances soil nitrogen without boosting microbial activity, and identifies soil moisture and carbon availability as key factors affecting nitrogen dynamics.
Background: Multiple sites of metastasis and desmoplastic reactions in the stroma are key features of human pancreatic cancer (PC). There are currently no simple and reliable animal models that can mimic these features for accurate disease modeling.
Aim: To create a new xenograft animal model that can faithfully recapitulate the features of human PC.
The effectiveness of cupping therapy on chronic fatigue syndrome: A single-blind randomized controlled trial.
Complement Ther Clin Pract
August 2020
Background: and purpose: We investigated the effectiveness of cupping therapy with three different pressures in patients with chronic fatigue syndrome (CFS).
Materials And Methods: The participants were randomly assigned to three groups, as follows: cupping pressure of -0.02 mpa (n = 38), -0.
Article Synopsis
- Human activities have increased nitrogen pollution in ecosystems, but its effects on soil carbon and nitrogen levels remain unclear in real-world conditions.
- A study in northern China's BTH region found that long-term nitrogen deposition has likely raised soil total nitrogen levels in forests, contrasting with previous findings.
- Importantly, soil moisture and pH, influenced by climate factors, were identified as key drivers of soil carbon and nitrogen variations, suggesting that climate change may have a greater impact than nitrogen pollution itself.
[Association of plasma insulin and its relevant factors with childhood hypertension].
Zhonghua Er Ke Za Zhi
February 2009