Multi-modal Wearable Patch for Localized Monitoring of Post-operative Skin Flap Transplantation.

Monitoring the status of skin flap transplantation (SFT) is crucial for early intervention, particularly to mitigate risks, such as necrosis and complications arising from poor vascularization or infection. Current clinical practices for monitoring SFT rely on intermittent gauze removal, risking secondary injury and delayed complication detection. While wearable sensors have been proposed, existing systems lack simultaneous and multi-parameter monitoring, poor wearability, and the ability to localize complications within the flap.

Relationship between competency inventory, perceived career benefits, and professional identity among pediatric nurses.

Objective: To investigate the relationship between competency inventory, perceived career benefits, and professional identity among pediatric nurses.

Methods: A convenience sampling method was used to select 444 pediatric nurses from 10 tertiary hospitals in Hebei Province between June 2023 and August 2023 as the research subjects. The survey was conducted on September 15, 2023, during the morning meetings (nurses who were not on duty that day were surveyed when they returned to work).

Janus channel of membranes enables concurrent oil and water recovery from emulsions.

Existing separation technologies struggle to recover oil and water concurrently from surfactant-stabilized emulsions to achieve the goal of near-zero liquid discharge. We present a Janus channel of membranes (JCM) that features a confined architecture constructed of a pair of hydrophilic and hydrophobic membranes, which allows for concurrent, highly efficient recovery of oil and water from surfactant-stabilized emulsions. The confined Janus channel can amplify the interplay of the membrane pair through a feedback loop that involves enrichment and demulsification.

Battery-Free and Multifunctional Microfluidic Janus Wound Dressing with Biofluid Management, Multi-Indicator Monitoring, and Antibacterial Properties.

The sophisticated environment of chronic wounds, characterized by prolonged exudation and recurrent bacterial infections, poses significant challenges to wound recovery. Recent advancements in multifunctional wound dressings fall short of providing comprehensive, accurate, and comfortable treatment. To address these issues, a battery-free and multifunctional microfluidic Janus wound dressing (MM-JWD) capable of three functions, including exudate management, antibacterial properties, and multiple indications of wound infection detection, has been developed.

Leveraging Janus Substrates as a Confined "Interfacial Reactor" to Synthesize Ultrapermeable Polyamide Nanofilms.

Porous substrates act as open "interfacial reactors" during the synthesis of polyamide composite membranes via interfacial polymerization. However, achieving a thin and dense polyamide nanofilm with high permeance and selectivity is challenging when using a conventional substrate with uniform wettability. To overcome this limitation, we propose the use of Janus porous substrates as confined interfacial reactors to decouple the local monomer concentration from the total monomer amount during interfacial polymerization.

T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1α/AMPK signaling axis.

T-2 toxin is one of the most toxic mycotoxins. People are primarily exposed to T-2 toxin through the consumption of spoiled food, typically over extended periods and at low doses. T-2 toxin can cause damage to articular cartilage.

Supergravity-Steered Generic Manufacturing of Nanosheets-Embedded Nanocomposite Hydrogel with Highly Oriented, Heterogeneous Architecture.

Designing nanocomposite hydrogels with oriented nanosheets has emerged as a promising toolkit to achieve preferential performances that go beyond their disordered counterparts. Although current fabrication strategies via electric/magnetic force fields have made remarkable achievements, they necessitate special properties of nanosheets and suffer from an inferior orientation degree of nanosheets. Herein, a facile and universal approach is discovered to elaborate MXene-based nanocomposite hydrogels with highly oriented, heterogeneous architecture by virtue of supergravity to replace conventional force fields.

Synthesis of sinomenine derivatives with potential anti-leukemia activity.

In recent years, with sinomenine hydrochloride as the main ingredient, Qingfengteng had been formulated as various dosage forms for clinical treatment. Subsequent findings confirmed a variety of biological roles for sinomenine. Here, 15 HS-donating sinomenine derivatives were synthesized.

Design of Photothermal "Ion Pumps" for Achieving Energy-Efficient, Augmented, and Durable Lithium Extraction from Seawater.

Extracting lithium from seawater has emerged as a disruptive platform to resolve the issue of an ever-growing lithium shortage. However, achieving highly efficient and durable lithium extraction from seawater in an energy-efficient manner is challenging, as imposed by the low concentration of lithium ions (Li) and high concentration of interfering ions in seawater. Here, we report a facile and universal strategy to develop photothermal "ion pumps" (PIPs) that allow achieving energy-efficient, augmented, and durable lithium extraction from seawater under sunlight.

Solid-state, liquid-free ion-conducting elastomers: rising-star platforms for flexible intelligent devices.

Soft ionic conductors have emerged as a powerful toolkit to engineer transparent flexible intelligent devices that go beyond their conventional counterparts. Particularly, due to their superior capacities of eliminating the evaporation, freezing and leakage issues of the liquid phase encountered with hydrogels, organohydrogels and ionogels, the emerging solid-state, liquid-free ion-conducting elastomers have been largely recognized as ideal candidates for intelligent flexible devices. However, despite their extensive development, a comprehensive and timely review in this emerging field is lacking, particularly from the perspective of design principles, advanced manufacturing, and distinctive applications.

Photothermal Janus fabrics enabling persistent directional sweat-wicking in personal wet-thermal management.

Directional sweat-wicking by Janus fabrics has gained substantial attention in promoting personal wet-thermal management for optimal human comfort. During intense physical exercise, excessive sweating can cause the flooding of fabrics and weaken their wicking capabilities once the inner capillary channels are saturated. To address this issue, we develop a photothermal Janus fabric through a facile polydopamine (PDA) deposition followed by single-sided spray-coating of hydrophobic polydimethylsiloxane (PDMS).

Balance between Activity and Stability of Single Metal and Intermetallic Compounds for Electrocatalytic Hydrogen Evolution Reaction.

The higher population of the antibonding state around the Fermi level will result in better activity yet lower stability of HER (Re vs Ru metal). There seems to be a limitation or balance for using a single metal since the bonding scheme of a single metal is relatively simple. Combining Re (strong bonding), Ru (HER active), and Zr metal (corrosion-resistant) grants ternary intermetallic compound ZrReRu, exhibiting excellent HER activity and stability in acidic and alkaline electrolytes.

A study on atypical Kashin-Beck disease: an endemic ankle arthritis.

Background: To study the epidemiological characteristics of atypical Kashin-Beck disease cases without characteristic hand lesions such as interphalangeal joint enlargement and brachydactyly and the characteristics of ankle joint lesions.

Methods: We investigated Kashin-Beck in the endemic villages in Heilongjiang Province. The patients were judged according to the "Diagnosis of Kashin-Beck Disease" (WS/T 207-2010).

Catalytic asymmetric synthesis of carboranylated diols bearing two adjacent stereocenters located at the α,β-position of -carborane cage carbon.

Despite the great interest in carborane-containing molecules, there is a lack of literature on the generation of central chiralities, catalytic asymmetric transformations using prochiral carboranyl substrates. Herein, we have synthesized novel optically active icosahedral carborane-containing diols Sharpless catalytic asymmetric dihydroxylation of carborane-derived alkenes, under mild conditions. The reaction showed a good substrate scope with 74-94% yields and 92->99% ee.

Associations of executive function and age of first use of methamphetamine with methamphetamine relapse.

Background And Aims: Methamphetamine (MA) is a psychostimulant associated with a high relapse rate among patients with MA use disorder (MUD). Long-term use of MA is associated with mental disorders, executive dysfunction, aggressive behaviors, and impulsivity among patients with MUD. However, identifying which factors may be more closely associated with relapse has not been investigated.

YAP plays a protective role in T-2 toxin-induced inhibition of chondrocyte proliferation and matrix degradation.

Previous research has shown that T-2 toxin can damage cartilage, resulting in a disease phenotype similar to osteoarthritis. The precise molecular mechanism by which T-2 toxin causes chondrocyte injury, however, is unknown. The purpose of this study was to look into the role of YAP in T-2 toxin-induced rat chondrocyte injury.

Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines.

Our previous studies have clarified that red nucleus (RN) interleukin (IL)-6 is involved in the maintenance of neuropathic pain and produces a facilitatory effect by activating JAK2/STAT3 and ERK pathways. In this study, we further explored the immune molecular mechanisms of rubral IL-6-mediated descending facilitation at the spinal cord level. IL-6-evoked tactile allodynia was established by injecting recombinant IL-6 into the unilateral RN of naive male rats.

Associations Between High-Sensitivity C-Reactive Protein and All-Cause Mortality Among Oldest-Old in Chinese Longevity Areas: A Community-Based Cohort Study.

Background: The association between high-sensitivity C-reactive protein (hsCRP) levels and all-cause mortality for the oldest-old (aged 80 years or older) remains unclear. We aimed to investigate the associations between hsCRP concentrations and the risks of all-cause mortality, and further identify the potential modifying factors affecting these associations among the oldest-old.

Methods: This prospective, community-based cohort study included 2,206 participants aged 80 years or older (median age 93.

Intraocular Lens with Mussel-Inspired Coating for Preventing Posterior Capsule Opacification via Photothermal Effect.

Phacoemulsification with implantation of intraocular lens (IOLs) has been widely applied as a standard treatment for cataract, which is the leading cause of vision impairment. However, it still remains a critical challenge to prevent posterior capsule opacification (PCO) in terms of postoperative visual quality. Herein, we report IOLs with mussel-inspired coatings for inhibiting lens epithelial cells and then preventing PCO through photothermal conversion effect.

Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.

Background: Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokines. Here, we further explored the action of red nucleus IL-33 in the early development of mononeuropathic pain.

Methods: In this study, male rats with spared nerve injury (SNI) were used as mononeuropathic pain model.

Surface Coatings via the Assembly of Metal-Monophenolic Networks.

Mussel-inspired surface modification has received significant interest in recent years because of its simplicity and versatility. The deposition systems are still mainly limited to molecules with catechol chemical structures. In this paper, we report a novel deposition system based on a monophenol, vanillic acid (4-hydroxy-3-methoxybenzoic acid), to fabricate metal-phenolic network coatings on various substrates.

Is vanishing twin syndrome associated with adverse obstetric outcomes of ART singletons? A systematic review and meta-analysis.

Purpose: The objective of our meta-analysis was to estimate the effect of VTS on obstetric outcomes of ART singletons.

Methods: PubMed, Embase, MEDLINE, and ClinicalTrials.gov were searched up to January 2019 to find studies reporting the obstetric outcomes of ART singletons with VTS.