Publications by authors named "Hao-Min Chen"

In the search for fast lithium-ion conducting solids for the development of safe rechargeable all-solid-state batteries with high energy density, thiophosphates and related compounds have been demonstrated to be particularly promising both because of their record ionic conductivities and their typically low charge transfer resistances. In this work we explore a wide range of known and predicted thiophosphates with a particular focus on the cubic argyrodite phase with a robust three-dimensional network of ion migration pathways. Structural and hydrolysis stability are calculated employing density functional method in combination with a generally applicable method of predicting the relevant critical reaction.

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In 2013, the first dengue fever (DF) outbreak in central China was reported in the central of Henan province, northern temperate regions, although they have been sequentially recorded in Southern China. 106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3 (DEN-3) infections. 62/392 (15.

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Article Synopsis
  • * Key methods included RNA extraction from isolated viruses, sequencing the amplified fragments, and conducting phylogenetic analysis using various software tools.
  • * Results indicated high genetic similarity between the two isolates, with both strains contributing to the main epidemic CVB5 circulation in Henan alongside other groups present in the region.
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  • Severe fever with thrombocytopenia syndrome (SFTS) is a deadly disease in China caused by New Bunyavirus, with a case fatality rate of around 12%, and currently has no vaccine or antiviral treatments available.
  • Researchers developed a new, rapid testing method called reverse transcription-loop-mediated isothermal amplification (RT-LAMP) to detect New Bunyavirus efficiently, with high accuracy and no false positives from similar viruses.
  • The RT-LAMP method showed 99% sensitivity and 100% specificity when compared to traditional real-time RT-PCR tests, making it a promising option for diagnosing SFTS, especially in hospitals with limited resources.
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This paper presents the experiences of five women's (of three nationalities and different ethnic backgrounds) challenging dominant cultural discourses and finding their own voice. Starting from a class assignment and individual papers, the five women engaged in a participatory writing project that helped them critically examine dominant discourses of their home countries, the US and other countries, and reflect on how they have been constrained by these dominant discourses and how they have resisted them.

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Molecular detection of enterovirus (EV)71 RNA based on PCR methods is a quick and sensitive approach. At present, different PCR-based methods for EV71 RNA detection are available, but comparisons of results obtained using different approaches are limited. This study is to compare the analytical sensitivity and specificity of different real-time reverse transcription-polymerase chain reaction (rRT-PCR) and conventional reverse transcription-polymerase chain reaction (cRT-PCR) assays for enterovirus and EV71 detection, Altogether, three rRT-PCR assays and one cRT-PCR assay targeting the 5'UTR gene for universal detection of enterovirus; two rRT-PCR assays andone cRT-PCR assay targeting the VP1 gene for specific detection of EV 71 were examined.

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Objective: To understand the epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis (JE) in Henan province in 2010.

Methods: A total of 433 selected JE cases in Henan province in 2010 were analyzed by descriptive epidemiological method. Xinyang and Luoyang were selected as survey sites in 2010.

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Objective: To understand etiological types and distribution features of hand-foot-mouth disease (HFMD) in Henan province between 2008 and 2011.

Methods: A total of 30 486 specimens of feces, rectal swabs or throat swabs from HFMD patients were collected by each Municipal CDC in Henan from 2008 to 2011. The enterovirus 71 (EV71), coxsackie virus A16 (CA16) and other enterovirus (EV) were detected by RT-PCR or real time RT-PCR.

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Article Synopsis
  • The study aimed to analyze the genomic characteristics of the coxsackievirus A16 (CoxA16) strain linked to hand-foot-mouth disease in Henan province, using 406 samples processed through RT-PCR and cell culture methods.
  • The entire genome of the CoxA16 isolate was sequenced, revealing a length of 7411 base pairs, and showed varying nucleotide similarities with other CoxA16 strains in specific genetic regions.
  • Phylogenetic analysis indicated that this strain belongs to the subgenotype C2/B-2 and clustered with strains from other locations, emphasizing its relevance for monitoring and controlling HFMD outbreaks.
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This report presents an overview of human enterovirus B species in Henan Province. A total of 14 isolates of HEV-B species isolated under HFMD surveillance network during the six months in 2010 were examined. Based on molecular typing results targeting VP1 region, 14 isolates were classified into 6 serotypes of HEV-B.

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Objective: To culture, isolate and identify new bunyavirus in Vero cell line.

Methods: Samples of 164 new bunyavirus positive by real time RT-PCR detection and well preserved serum specimens were selected from cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Xinyang, Henan province in 2009 - 2011. These sera were cultured in Vero cell line and new bunyavirus were detected by observing cytopathic effect (CPE), Real-time RT-PCR, indirect immunofluorescence assay (IFA) and thin-section electron microscopy observation.

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Objective: To develop an indirect immunofluorescence assay (IFA) for detection of IgG antibodies against new bunyavirus.

Methods: The antigen slides were prepared with 5 new bunyavirus strains isolated using Africa green monkey kidney (Vero) cells. Specificity and sensitivity evaluation of IFA were carried out by optimizing working conditions of IFA.

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Objective: To analyze and summarize the clinical characteristics, experience of diagnosis and treatment of cases infected by new bunyavirus, which occurred in Henan province in 2010.

Methods: The clinical characteristics and effect of diagnosis and treatment of 5 cases were analyzed using descriptive epidemiological method. Blood specimens were detected by RT-PCR and pathogen separation.

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Objective: To analyze the epidemiological characteristics of fever thrombocytopenia and leukopenia syndrome (FTLS) in Henan province, China in 2007 - 2011.

Methods: Data from specific surveillance system for FTLS in Henan and Information Management System of Chinese Center for Disease Control and Prevention were used to collect the information of the cases.Descriptive epidemiological methods were used to analyze the surveillance data during 2007 - 2011.

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Objective: To analyze the epidemiological characteristics and risk factors of Japanese encephalitis (JE) in Henan province.

Methods: Epidemiological characteristics and related factors of JE cases in Henan province from 2006 to 2010 were analyzed with descriptive epidemiological method and JE IgM antibodies of the serum or cerebrospinal fluid of the cases were detected by ELISA.

Results: 3099 cases were reported in Henan province from 2006 to 2010.

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To demonstrate and evaluate five different methods in the determination of temporal clustering on infectious diseases. The incidence rates of bacillary dysentery in Jinshui district, Zhengzhou city, Henan province from 2008 to 2010 were analyzed by 5 different methods-Cluster Analysis, Runs Test, Negative Binomial Distribution, Circular Distribution and Concentration Ratio. Through Cluster Analysis, data showed that the epidemic period was from May to Sept.

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Objective: To isolate and identify the pathogen that caused an outbreak of viral encephalitis in Henan province in 2010; and to analyze the genetic characteristic of gene viral protein1(VP1) on the viral strains isolated.

Methods: During the period of the outbreak of viral encephalitis in Lushan county, Pingdingshan city, Henan province, eight hospitalized patients were recruited in the study. All the patients' feces samples were collected.

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Objective: To study the spatial distribution and dynamics of human rabies cases at the county level, in Henan province to provide scientific evidence for the development of control program on rabies.

Methods: Data of human rabies cases at the county level from 2004 to 2010 in Henan province were analyzed by Poisson distribution and negative binomial distribution. Data calculation was conducted manually.

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To reveal the genetic features and recombination of enterovirus 71 isolates between 2008 and 2010. A total of 5 enterovirus 71 isolates were sequenced completely and phylogenetic analysis and recombination were performed. Phylogenetic analysis based on VP1 regions revealed that the Henan enterovirus 71 between 2008 and 2010 belonged to C4a in subgenotype C4.

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Background: Clinical competency certifications are important parts of internal medicine residency training. This study aims to evaluate a composite objective structured clinical examination (OSCE) that assesses postgraduate year-1 (PGY(1)) residents' acquisition of the six core competencies defined by the Accreditation council for Graduate Medical Education (ACGME).

Methods: Six-core-competency-based OSCE was used as examination of the clinical performance of 192 PGY(1) residents during their 3-month internal medicine training between 2007 January and 2009 December.

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