Publications by authors named "Hao-Lin Li"
Article Synopsis
- High-grade serous ovarian cancer (HGSOC) is a serious type of ovarian cancer that originates from a specific precursor lesion called serous tubal intraepithelial carcinoma, and its molecular subtypes are crucial for determining prognosis and pathology.
- The paper critiques existing classification methods for HGSOC based on early integration of multi-omics data, which often overlook the interactions between different omics layers, leading to ineffective feature learning and redundancy in data.
- To address these issues, the authors propose a new method called MMDAE-HGSOC, which utilizes a multi-modal deep autoencoder to better integrate various omics data types and employs S-LASSO for identifying relevant genes tied to HGSOC subtypes, showing improved
Phytoremediation of cadmium (Cd) contaminated soils by accumulators or hyperaccumulators has received considerable attention. However, there is still limited information about its migration, dynamic characteristics, and interaction with microbial communities in rhizosphere. In this study, the behaviors of Cd in rhizosphere soils in phytoremediation were carefully studied and illustrated.
View Article and Find Full Text PDFHBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line.
Biochem Biophys Res Commun
May 2009
The relationships between epithelial-to-mesenchymal transition (EMT), hepatitis B virus X protein (HBx), and the non-receptor tyrosine kinase c-Src were investigated. The HBx gene transfected SMMC-7721 cells underwent morphological changes from a classic epithelial morphology to a spindle-like shape. The HBx transfection increased the invasive potential of these cells.
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