[Circular RNA-Encoded Proteins in Gastrointestinal Cancer:A Review].

Circular RNAs(CircRNAs)are a class of non-coding RNAs with a covalently closed-loop structure,high stability,and tissue specificity,with the production mechanisms different from linear RNAs.Recent studies have discovered that some CircRNAs can encode proteins via cap-independent translation mechanisms such as internal ribosome entry site,N6-methyladenosine,and rolling loop translation.The encoded proteins regulate homologous linear proteins or downstream signaling pathways via protein bait or other mechanisms,thereby exerting biological functions.

Mechanical Thrombectomy in Anticoagulated Patients With Acute Ischemic Stroke: A Meta-Analysis.

Background: According to a previous studies, mechanical thrombectomy(MT) is safe for anticoagulated patients. However, the safety and prognosis of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKA) have not been compared with those of MT.This meta-analysis aimed at determining the efficacy of DOACs or VKA for patients after MT.

Medial Protrusio Technique Versus Structural Autologous Bone-Grafting Technique in Total Hip Arthroplasty for Crowe Type II to III Hip Dysplasia.

Background: It is unclear whether acetabular reconstruction techniques have any impact on clinical outcomes. This study aimed to determine (1) whether acetabular reconstruction techniques influenced the position of the acetabular cup and (2) whether clinical outcomes based on the acetabular reconstruction techniques differ in patients undergoing total hip arthroplasty (THA) with Crowe II to III developmental dysplasia of the hip.

Methods: This was a retrospective analysis of prospectively collected data from 69 patients (74 hips) who were treated with cementless THA using medial protrusio technique (MPT) or structural autologous bone-grafting technique (SABT).

Long non-coding RNA-LINC00941 promotes the proliferation and invasiveness of glioma cells.

Glioma is one of the most common intracranial malignant tumors worldwide, accounting for 30%-40% of primary brain tumors. Long non-coding RNAs (lncRNAs) have been implicated in cancer malignant progression. Glioma is classified into multiple subtypes, but lncRNA expression pattern in different subtypes are not fully described.

Antidepressant-like effects of Z-ligustilide on chronic unpredictable mild stress-induced depression in rats.

Depression is a significant public health issue and its neuropathogenesis is associated with the dysfunction of progesterone and allopregnanolone biosynthesis. Z-ligustilide (LIG), one of the main components of the herb (AS), is reported to have antidepressant activities. The present study aimed to evaluate the antidepressant-like effects of LIG via behavioral tests and to measure the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus.

[Community structure of zooplankton in adjacent area of Changjiang Estuary, China in summer 2016.].

Based on the data of zooplankton samples from 27 stations in the offshore area of Changjiang Estuary in August 2016, we analyzed the community structure and diversity of zooplankton and examined the relationship between zooplankton community structure and environmental factors. A total of 108 species of zooplankton belonging to 12 groups in six phyla, together with 15 types of pelagic larvae and fish eggs were identified. The main groups were copepods, thaliacea, chaetognaths, cladocladus and medusae, with the average abundance being 273.

Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin.

microRNA (miR)-612 shows anticancer activity in several types of cancers, yet its function in melanoma is still unclear. This study was undertaken to investigate the expression of miR-612 and its biological relevance in melanoma cell growth, invasion, and tumorigenesis. The expression and prognostic significance of miR-612 in melanoma were examined.

Experimental proposal for performing nonlocal measurement of a product observable.

Due to the restrictions on quantum measurement imposed by relativistic causality, it is not easy to perform a nonlocal measurement on spacelike separated systems instantaneously. Here we design an experiment in an optical system to perform the nonlocal measurement of a product observable on a two-qubit system, where a maximally-entangled two-qubit state, acting as an ancillary meter, and three identical Kerr media are used to couple the system under consideration and the target meter. It is shown that the nonlocal measurement of the product observable, σzA⊗σzB, which has two degenerate eigenvalues, could be implemented in a deterministic way without violating relativistic causality.

Tracing the trajectory of photons through Fourier spectrum.

By slightly vibrating the mirrors in an interferometer at different frequencies, the photons' trajectory information is stored in the light beam. To read out this information, we record the centroid location of the intensity distribution of output beam and Fourier analyze its time evolution. It is shown that every vibrating mirror contributes a peak in the Fourier spectrum.

Biomimetic semisynthesis of arglabin from parthenolide.

The semisynthesis of arglabin, an anticancer drug in clinical application, is developed from abundant natural product parthenolide via three steps. Each step in this sequence is highly stereoselective, and the substrate-dependent stereoselectivity in the epoxidation step can be explained by computational calculations. The success of chemical semisynthesis of arglabin suggests that the biosynthesis of arglabin might proceed in a similar pathway.