Publications by authors named "Hao-Liang Sun"
J Am Heart Assoc
July 2024
Article Synopsis
- The study investigates the effects of rhCHK1, a recombinant protein, on improving heart cell survival and growth after ischemia/reperfusion injury in pigs, with findings suggesting enhanced cardiac repair and function.
- Researchers found that injecting rhCHK1 not only stimulated heart cell division and reduced inflammation within days but also improved overall heart function and minimized damage over a month post-injury.
- The mechanism behind these effects involves CHK1 binding to and activating specific sites on the PKM2 protein, leading to changes in metabolism that support heart cell renewal and repair processes.
