Publications by authors named "Hao-Li Wang"

Article Synopsis
  • IBS-D is a tummy problem that causes pain and diarrhea, and it can be affected by stress and other factors.
  • The study found that stress leads to too much xanthine in the gut and changes helpful bacteria, which affects how the gut works.
  • This research can help scientists understand why people with IBS-D feel bad and could help create new medicines for them.
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Article Synopsis
  • IRF3 and IRF7 are key players in regulating antiviral responses by managing the production of type I interferon (IFN-I) following viral infection.
  • The study shows that the protein XAF1, which interacts with IRF7, plays a crucial role in limiting IRF7 activity to prevent excessive IFN-I production, highlighting its importance in immune balance.
  • Additionally, the research uncovers a pathway involving XAF1, XIAP, and KLHL22 that influences the stability of IRF7, suggesting a novel target for enhancing antiviral immunity.
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Article Synopsis
  • The study aimed to assess how different sperm counting chamber designs impact sperm motility using computer-assisted analysis techniques.
  • The drop-filled Makler chamber showed significantly better results in terms of motility and other sperm kinetic parameters compared to the Leja chambers.
  • Structural features of the Leja chambers, like the coverslip thickness and edge shape, did not significantly affect sperm analysis outcomes.
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Inflammatory bowel disease (IBD) mainly includes Crohn's disease (CD) and ulcerative colitis (UC). Immune disorders play an essential role in the pathogenesis of these two IBDs, but the differences in the immune microenvironment of the colon and their underlying mechanisms remain poorly investigated. Here we examined the immunological features and metabolic microenvironment of untreated individuals with IBD by multiomics analyses.

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Frequent outbreaks of viruses have caused a serious threat to public health. Previous evidence has revealed that DNA methylation is correlated with viral infections, but its role in innate immunity remains poorly investigated. Additionally, DNA methylation inhibitors promote IFN-I by upregulating endogenous retrovirus; however, studies of intrinsically demethylated tumors do not support this conclusion.

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Physical or mental stress leads to neuroplasticity in the brain and increases the risk of depression and anxiety. Stress exposure causes the dysfunction of peripheral T lymphocytes. However, the pathological role and underlying regulatory mechanism of peripheral T lymphocytes in mood disorders have not been well established.

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Background: Anterior odontoid screw fixation (AOSF) has been suggested as the optimal treatment for type II and some shallow type III odontoid fractures. However, only the classical surgical trajectory is available; no newer entry points or trajectories have been reported.

Methods: We evaluated the anatomic feasibility of a new trajectory for AOSF using 3-dimensional (3D) screw insertion simulation software (Mimics).

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