Publications by authors named "Hao-Jie Shi"
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.
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- Long noncoding RNAs (lncRNAs), particularly lncRNA FAF, are being studied for their significant roles in cardiovascular diseases, specifically in regulating protein expression in heart cells.
- Researchers performed high-throughput RNA sequencing to identify changes in lncRNAs and messenger RNAs in rats with acute myocardial infarction (AMI) compared to healthy controls, revealing that lncRNA FAF levels were decreased in the affected tissues.
- The study found that overexpressing lncRNA FAF could protect cardiomyocytes from apoptosis (cell death) during ischemia and hypoxia, potentially by enhancing the expression of FGF9, which also plays a protective role via specific signaling pathways.
Objectives: We aimed to assess the effect of selective intracoronary hypothermia on outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
Background: Intracoronary hypothermia, the feasibility and safety of which has been validated in humans, induced by selective trans-coronary infusion of saline at different temperatures can reduce infarct size (IS) prior to reperfusion in animal models of STEMI.
Methods: Sixty STEMI patients presenting with thrombolysis in myocardial infarction (TIMI) flow grade 0/1 were randomized after coronary artery angiography.
Article Synopsis
- Congestive heart failure (CHF) is linked to reduced potassium current (I), leading to longer action potentials (APs) and increased risk of ventricular arrhythmias, although the precise mechanisms are not fully understood.
- Research found that in rats with CHF, Kcna2 mRNA was reduced by 43%, and knocking down Kcna2 exacerbated AP prolongation and arrhythmias, while its overexpression had protective effects.
- Kcna2 antisense RNA (AS) levels increased in CHF, suggesting that targeting Kcna2 AS could help prevent or treat ventricular arrhythmias by restoring potassium current and normalizing AP durations.
Article Synopsis
- - The study aimed to investigate how working hours and physical activity in the workplace relate to the development of coronary heart disease (CHD) in a Chinese population.
- - Researchers surveyed 595 participants (both with and without CHD) aged 24 to 65, using questionnaires and logistic regression to analyze data collected between December 2015 and October 2016.
- - Findings revealed that long working hours (≥55 hours/week) and sedentary behavior at work significantly raised the risk of CHD, even when leisure time physical activity was considered.
Article Synopsis
- EGCG, a compound in green tea, has protective effects against cardiovascular diseases by influencing key proteins involved in atherosclerosis and plaque instability.
- The study found that EGCG (at 1 µM concentration) reduces the expression of MMP-9 and MCP-1 in macrophages exposed to LPS, while also inhibiting the MAPK and NF-κB pathways.
- These effects are mediated through the TLR4 receptor and its regulator Tollip, with EGCG potentially binding to a specific cellular receptor to exert its influence.
Association between pet ownership and coronary artery disease in a Chinese population.
Medicine (Baltimore)
March 2017
Article Synopsis
- A study conducted in Nanjing, China, examined the link between pet ownership and coronary artery disease (CAD) in 561 patients from October 2015 to May 2016.
- *Results indicated that pet ownership is associated with a reduced risk of CAD, with dog owners showing a particularly lower risk compared to cat owners.
- *Moreover, longer duration of pet ownership and increased time spent playing with pets were linked to even lower CAD risk, highlighting pet ownership as a potential protective factor in cardiovascular health.