Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates.

Objective: Autonomic neuropathy is a major component of familial amyloid polyneuropathy (FAP) due to mutated transthyretin, with sudomotor failure as a common manifestation. This study aimed to investigate the pathology and clinical significance of sudomotor denervation.

Methods: Skin biopsies were performed on the distal leg of FAP patients with a follow-up duration of 3.