Publications by authors named "Hao-Chen Chi"
Background: Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.
Methods: The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline.
Article Synopsis
- The study investigates how variations in the BIN1 gene are linked to neuroinflammation and Alzheimer's disease (AD) pathology, focusing on two specific genetic polymorphisms: rs7561528 and rs744373.
- Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Chinese Alzheimer's Biomarker and Lifestyle (CABLE) study, researchers found a significant relationship between BIN1 loci and levels of key Alzheimer's biomarkers in cerebrospinal fluid (CSF), particularly phosphorylated-tau (P-tau), total-tau (T-tau), and microglial activation marker sTREM2.
- The findings suggest that the association between BIN1 loci and tau pathology is
Article Synopsis
- Patients with transient ischemic attack (TIA) or ischemic stroke face a heightened risk of cognitive decline, potentially linked to the interaction of ischemic cerebrovascular disease (ICVD) with biomarkers related to dementia.
- In a study of 2,524 participants, higher levels of total-tau (t-tau) in cerebrospinal fluid were associated with poorer cognitive performance, with t-tau identified as a partial mediator in this relationship.
- The findings suggest that targeting brain ischemia and reducing neuronal damage could be a valuable strategy in preventing cognitive decline in these patients.
Background: Frailty is a vulnerability state increasing the risk of many adverse health outcomes, but little is known about the effects of frailty on neuropsychiatric health.
Objective: To explore the associations between frailty and the risk of neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD), especially in its different clinical stages.
Methods: We included 2,155 individuals assessed using modified frailty index-11 (mFI-11), Neuropsychiatric Inventory (NPI) and Neuropsychiatric Inventory Questionnaire (NPI-Q) in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Article Synopsis
- * Analyzing data from over 312,000 participants, the researchers found that higher levels of nitrogen oxides (NO) and particulate matter (PM) were associated with an increased risk of PD, especially for those with significant genetic risks.
- * Results indicate that individuals exposed to higher pollution levels and with a genetic predisposition are at a much greater risk of developing PD, highlighting the need for awareness of environmental and genetic factors in PD.