Investigating the impact of multidimensional sleep traits on cardiovascular diseases and the mediating role of depression.

Background: Observational studies have reported that sleep is associated with the risk of major depressive disorder (MDD) and cardiovascular diseases (CVDs). However, the causal relationships among various sleep traits remain contentious, and whether MDD mediates the impact of specific sleep traits on CVDs is unclear.

Methods: We performed two-sample Mendelian randomisation analyses to explore whether insomnia, sleep time, daytime napping, daytime sleepiness, chronotype, snoring or obstructive sleep apnoea were causally associated with the risk of five CVDs, including coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), atrial fibrillation and stroke.

Climate and biological factors jointly shape microbial community structure in the Yarlung Zangbo River during the dry season.

Microorganisms are crucial components of aquatic ecosystems, playing key roles in biogeochemical cycles. Understanding microbial diversity and community assembly mechanisms is essential for river management and sustainable utilization of freshwater resources. However, the role of inter-microbial taxonomic group relationships in shaping community structures within high-altitude river ecosystems is unclear.

Cost Utility Analysis of Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder: Randomized Controlled Trial.

Background: Unguided internet-based cognitive behavioral therapy (ICBT) has been proven effective for major depressive disorder (MDD). However, few studies have examined its cost-effectiveness in low-resource countries and under nonspecialist routine care.

Objective: This study aimed to evaluate the short- and long-term cost utility of unguided ICBT compared to a waitlist control for persons with MDD from the perspectives of society and the health care system.

FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage.

Introduction: Cochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum autophagy (ER-phagy) receptor, plays an important part in the dynamic remodelling of the ER, the mutation of which affects sensory and autonomic neurons. However whether FAM134B-mediated ER-phagy involved in Cis-induced SGN damage or not was unknown.

CAR+ T-Cell Lymphoma after Cilta-cel Therapy for Relapsed or Refractory Myeloma.

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel (cilta-cel) in the phase 3 CARTITUDE-4 trial. Monoclonal T cells from both patients had detectable CAR transgene expression and integration. The clinicogenomic features of these CAR transgenic T-cell lymphoproliferative neoplasms suggest that multiple potential intrinsic or extrinsic factors (or both) contributed to their pathogenesis, such as transduction of preexisting -mutated T cells, followed by acquisition of further oncogenic genomic variants.

Cannabidiol-loaded hydrogel microneedle patches inhibit TRIM14/TRAF3/ NF-κB axis for the treatment of psoriasis.

Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinized cells and infiltration of inflammatory cells that affects many patients worldwide. There is no cure for psoriasis, and its pathogenesis has not yet been fully elucidated. Alterations in some TRIM family proteins have been demonstrated to be involved in the exacerbation of psoriasis, however, the molecular mechanism of TRIM14 in psoriasis is unknown.

Reactivatable stimulated emission depletion microscopy using fluorescence-recoverable nanographene.

Stimulated emission depletion (STED) microscopy, a key optical super-resolution imaging method, has extended our ability to view details to resolution levels of tens of nanometers. Its resolution depends on fluorophore de-excitation efficiency, and increases with depletion laser power. However, high-power irradiation permanently turns off the fluorescence due to photo-bleaching of the fluorophores.

Resonance-enhanced multiphoton ionization detection of vibrationally excited O2.

We report a rotationally resolved spectroscopic detection scheme for vibrationally excited molecular oxygen with high sensitivity. Two-color (2 + 1') resonance-enhanced multiphoton ionization (REMPI) spectra of O2 hot bands were recorded for the first time via the 3dπ(v'=0)←X3Σg- (v″ = 1) Rydberg transitions. Spectroscopic constants and relative Franck-Condon factors were extracted and compared to simulations.

Optimization of Fermentation Conditions for Increasing Erucamide Content in Using Several Accelerants.

As a food packaging sliding agent, erucamide is widely used in the field of food packaging, but the traditional synthesis method of erucamide faces the problems of insufficient raw materials and low yield of colza oil. Our laboratory has found that L2 has the potential to produce erucamide. This study aims to improve the ability of L2 to produce erucamide by adding various accelerants to optimize the fermentation conditions.

Social isolation and loneliness increase the risk of coronary heart disease: Insights from a prospective cohort study.

Social isolation and loneliness are associated with an increased risk of various diseases and all-cause mortality. Coronary heart disease (CHD) is the main cause of heart disease deaths worldwide, which affects people's quality of life and longevity. However, the causal relationship between social isolation, loneliness, and CHD remains uncertain.

The Relationship between Parental Smartphone Addiction and Preschool Children's Emotional Regulation.

Objective: The objective of this study was to examine the relationship between parental smartphone addiction and preschool children's emotional regulation.

Methods: A total of 818 preschool children, aged between 3 and 6 years, and their fathers and mothers were included in the study. Data were collected using the Chinese version of the Emotional Regulation Checklist and the Chinese version of the Mobile Phone Problem Use Scale.

Analysis of Residual Stress at the Interface of Epoxy-Resin/Silicon-Wafer Composites During Thermal Aging.

During the thermal aging process of epoxy resin, microcracks, interfacial delamination, and warpage are the key factors leading to semiconductor device damage. Here, epoxy-resin specimens (EP-Ss) and epoxy-resin/silicon-wafer composites (EP-SWs) were prepared to analyze the distribution of residual stress (RS) in epoxy resin and its thermal aging process changes. The uniaxial tensile approach and Raman spectroscopy (RAS) showed that the peak shift of aliphatic C-O in EP-Ss was negatively correlated with the external stress, and that the stress correlation coefficient was -2.

The role of preoperative serum thyroglobulin in the diagnosis and treatment of differentiated thyroid cancer: a systematic review and meta-analysis.

Background: Serum thyroglobulin (Tg) is a critical marker for monitoring tumor recurrence and metastasis in patients who have undergone total thyroidectomy for differentiated thyroid cancer (DTC). While the definitive role of preoperative serum Tg in DTC is not yet established, studies suggest its importance in differentiating between benign and malignant thyroid nodules with indeterminate cytology, as well as in predicting distant metastasis (DM) in patients with DTC.

Methods: A thorough literature review was conducted on the use of preoperative serum Tg in differentiating between benign and malignant thyroid nodules, and in evaluating the extent of DTC lesions.

Sesamol Ameliorates Lipid Deposition by Maintaining the Integrity of the Lipid Droplet-Mitochondria Connection in Diabetic Nephropathy.

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause of end-stage renal disease (ESRD). However, there is still a lack of effective prevention and treatment strategies in clinical practice. As a metabolic disease, DN is accompanied by renal ectopic lipid deposition, and the deposited lipids further aggravate kidney injury.

Prevalence of lipophilic phycotoxins with different forms in the benthic environments of a typical mariculture bay.

Lipophilic phycotoxins (LPTs) are toxic and lipophilic secondary metabolites produced by toxic microalgae, which pose a serious threat to marine shellfish culture industries. LPTs were systematically investigated in bottom seawater, suspended particulate matter (SPM), sediment, and sediment porewater of Laizhou Bay, a typical mariculture bay in China, to understand the chemical diversity and environment behaviors of LPTs in the benthic environments. Okadaic acid (OA), pectenotoxin-2 (PTX2), dinophysistoxin-1 (DTX1), azaspiracid-2 (AZA2), gymnodimine (GYM), pectenotoxin-2 seco acid (PTX2 SA), 7-epi- pectenotoxin-2 seco acid (7-epi-PTX2 SA), 13-desmethylspirolide C (SPX1), yessotoxin (YTX) and homo YTX (h-YTX) were detected in the benthic environment of Laizhou Bay in spring, indicating that LPTs are rich in chemical diversity.

Identification of hub biomarkers in liver post-metabolic and bariatric surgery using comprehensive machine learning (experimental studies).

Background: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 30%, and the condition can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Metabolic and bariatric surgery (MBS) has been shown to be effective in treating obesity and related disorders, including NAFLD.

Objective: In this study, comprehensive machine learning was used to identify biomarkers for precise treatment of NAFLD from the perspective of MBS.

Case report: Giant meningioma of the left hemisphere.

Meningiomas are some of the most prevalent primary brain tumors in adults, and are typically non-neuroglial in nature. A variety of symptoms may be observed, including headaches, fluctuations in mental status, ataxia, muscle weakness, nausea and vomiting, seizures, visual changes, speech disorders, and sensory abnormalities. The World Health Organization (WHO) has a grading system for meningiomas based on histological criteria, which is as follows: Grade 1 meningiomas are considered benign; Grade 2 meningiomas have a moderately aggressive nature and usually present with histological atypia; and Grade 3 meningiomas exhibit aggressive malignant behavior.

Nanographene-Based Polymeric Nanoparticles as Near-Infrared Emissive Neuronal Tracers.

Precise tracking of axonal transport is key to deciphering neuronal functions. To achieve long-term imaging at both ultrastructural and macroscopic resolutions, it is critical to develop fluorescent transport tracers with high photostability and biocompatibility. Herein, we report the investigation of nanographene (NG)-based polymeric nanoparticles (NPs) as near-infrared (NIR)-emissive neuronal tracers.

Amylopectin-based Hydrogel Probes for Brain-machine Interfaces.

Implantable neural probes hold promise for acquiring brain data, modulating neural circuits, and treating various brain disorders. However, traditional implantable probes face significant challenges in practical applications, such as balancing sensitivity with biocompatibility and the difficulties of in situ neural information monitoring and neuromodulation. To address these challenges, this study developed an implantable hydrogel probe capable of recording neural signals, modulating neural circuits, and treating stroke.

Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population-based cohort study.

The global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal association between BA acceleration and incident HF risk, assess its modifying effect on genetic susceptibility, and how much BA acceleration mediates the impact of modifiable health behaviors on incident HF. We analyzed 274,608 UK Biobank participants without HF at baseline.

Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study.

Stroke risk increases with chronological age, but the relationship with biological age (BA) acceleration is poorly understood. We aimed to examine the association between BA acceleration and incident stroke and its subtypes, explore the modifying effects on genetic susceptibility, and assess how BA acceleration mediates the effect of behavior score. We studied 253,932 UK Biobank participants and computed two BA measures (Klemera-Doubal Method [KDM], Phenotypic Age [PhenoAge]), with BA acceleration calculated by regressing BA on chronological age.

Agenda Setting in Outpatient Consultation of Older Adults With Long-COVID.

Introduction: Agenda setting in doctor-patient interaction refers to the process when various agendas are presented and responded to. This study revealed how Long-COVID (LC) agenda items are managed by older adults and doctors during outpatient consultations.

Methods: Based on audio recordings, we adopted Conversation Analysis (CA) to unveil under what circumstances the patient or the doctor set the agenda and how they collaboratively work to develop an LC topic.

Heavy metals in sediments of the river-lake system in the Dianchi basin, China: Their pollution, sources, and risks.

The accumulation of heavy metals in river and lake sediments in basins seriously threatens ecological safety and human health. To manage the basin effectively, it is crucial to understand pollution levels and identify and quantify the sources and risks of heavy metals in rivers and lakes separately for targeted control. In this study, 34 sediment samples were collected from the Dianchi Basin, China, and the pollution, sources, and risks in the river-lake system sediments were systematically analysed for cadmium (Cd), chromium (Cr), arsenic (As), mercury (Hg), lead (Pb), copper (Cu), zinc (Zn), and nickel (Ni).