Developing Topics.

Background: Sabirnetug (ACU193) is a humanized monoclonal antibody targeting soluble amyloid beta (Aβ) oligomers, which are early contributors to the pathogenesis of Alzheimer's Disease (AD). An ultrasensitive assay was developed to measure sabirnetug pharmacokinetics (PK) in CSF of individuals with early AD in the Phase 1 study INTERCEPT-AD (NCT04931459).

Method: The immunoassay was developed on the Meso Scale Diagnostics (MSD) S-PLEX with improved sensitivity through TURBO-TAG® technology.

Developing Topics.

Background: Sabirnetug (ACU193) is a humanized IgG2 antibody targeting soluble, synaptotoxic amyloid β oligomers (AβOs). AβOs accumulate in Alzheimer's disease (AD) and induce pre- and post-synaptic changes, resulting in dendritic spine loss, neuronal degeneration, and release of synaptic proteins into the CSF. Recently, we reported that three administrations of sabirnetug in an early AD population (INTERCEPT-AD Phase 1 study, NCT04931459) significantly lowered CSF levels of the post-synaptic protein neurogranin as well as pTau181.

Dementia Care Research and Psychosocial Factors.

Background: Large language models (LLMs) provide powerful natural language processing capabilities in medical and clinical tasks. Evaluating LLM performance is crucial due to potential false results. In this study, we assessed ChatGPT and Llama2, two state-of-the-art LLMs, in extracting information from clinical notes, focusing on cognitive tests, specifically the Mini Mental State Exam (MMSE) and Cognitive Dementia Rating (CDR).

Endoplasmic reticulum stress causes long bone shortening in P4hb mice: A mouse model exhibiting significant features of cole-carpenter syndrome driven by P4HB mutations.

Cole-Carpenter syndrome (CCS) is a rare autosomal-dominant genetic disease characterized by craniosynostosis, ocular proptosis, hydrocephalus, distinctive facial features, and bone fragility. Previous cases of CCS are associated with genetic variations in P4HB, which encodes the protein disulfide isomerase (PDI), a key enzyme in protein folding. Patients with CCS caused by P4HB mutations often present with short stature, limb deformities, and abnormal epiphyseal plates.

Effect of Ropivacaine Combined with Nalbuphine in Erector Spinae Plane Block on Postoperative Analgesia in Lumbar Trauma Surgery: A Single-Center Randomized Controlled Trial.

Background: The erector spinae plane block (ESPB) has been increasingly utilized for postoperative analgesia in thoracic, abdominal, and spinal surgeries. This study evaluated the postoperative analgesic outcomes of ESPB with nalbuphine as a ropivacaine adjuvant for lumbar trauma surgery.

Methods: This randomized double-blind clinical trial included 57 participants who underwent lumbar trauma surgery.

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics.

Purpose: Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometry. Analyzing fluorophotometric data depends, inter alia, on the volume of aqueous humor in the anterior chamber but not the posterior chamber. Previous fluorophotometric studies of the aqueous inflow rate in mice have assumed the ratio of anterior:posterior volumes in mice to be similar to those in humans.

Anomaly detection in virtual machine logs against irrelevant attribute interference.

Virtual machine logs are generated in large quantities. Virtual machine logs may contain some abnormal logs that indicate security risks or system failures of the virtual machine platform. Therefore, using unsupervised anomaly detection methods to identify abnormal logs is a meaningful task.

Enhancing Neuron Activity Promotes Functional Recovery by Inhibiting Microglia-Mediated Synapse Elimination After Stroke.

Background: Activating glutamatergic neurons in the ipsilesional motor cortex can promote functional recovery after stroke. However, the underlying molecular mechanisms remain unclear. Clarifying key molecular mechanisms involved in recovery could help understand the development of neuromodulation strategies after stroke.

Reducing Disorder in PbTe Nanowires for Majorana Research.

Material challenges are the key issue in Majorana research, where surface disorder constrains device performance. Here, we tackle this challenge by embedding PbTe nanowires within a lattice-constant-matched crystal. The wire edges are shaped by self-organized growth instead of lithography, resulting in nearly atomically flat facets along both cross-sectional and longitudinal directions.

HSF-IBI: A Universal Framework for Extracting Inter-Beat Interval from Heterogeneous Unobtrusive Sensors.

Heartbeat inter-beat interval (IBI) extraction is a crucial technology for unobtrusive vital sign monitoring, yet its precision and robustness remain challenging. A promising approach is fusing heartbeat signals from different types of unobtrusive sensors. This paper introduces HSF-IBI, a novel and universal framework for unobtrusive IBI extraction using heterogeneous sensor fusion.

Non-Contact Stable Arterial Pulse Measurement Using mmWave Array Radar.

Pulse signals can serve as important indicators of one's cardiovascular condition. However, capturing signals with stable morphology using radar under varying measurement periods remains a significant challenge. This paper reports a non-contact arterial pulse measurement method based on mmWave radar, with stable signals achieved through a range-angle focusing algorithm.

Effects of on Growth Performance, Carcass Quality, Serum Indicators, Intestinal Morphology, and Digestive Enzymes in Broilers.

The purpose of this experiment is to investigate how different doses of powder affect the growth performance, carcass quality, serum biochemical indexes, serum antioxidant and immunological index, intestinal morphology, and digestive enzyme activity of broilers. Four hundred chicks of a similar weight (1 day old) are randomly assigned to four groups of five replicates of 20 chicks each (half males and half females). The control group is fed a basal ration, and the experimental groups T1, T2, and T3 are supplemented with 6.

Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.

Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation.

PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. The roles of PTEN-induced kinase 1 (PINK1) and peroxiredoxin-2 (Prdx2) in HFpEF pathogenesis remain unclear.

Objective: This study aimed to investigate the interaction between PINK1 and Prdx2 to mitigate cardiac diastolic dysfunction in HFpEF.

Microbial perspective of multidisciplinary collaborative weight management approach: may serve as a key target for weight loss.

Changes in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along with alterations in the structure, interactions, and metabolic functions of the microbiota.

Interaction of AURKA with TRIM28 revives dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis.

Background: Specific molecular mechanisms by which AURKA promoted LSCC metastasis were still unknown.

Methods: Bioinformatic analysis was performed the relationship between TRIM28 and LSCC. Immunohistochemistry, Co-IP assay, Rt-PCR and Western Blot were used to examine the expression of related molecular.

Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson's disease.

The relationship between hearing loss (HL) and Parkinson's disease (PD) remains unclear. Using individual-level and summary-level data from the UK Biobank and the largest genome-wide association studies, we examined this link through observational, Mendelian randomization and genetic pleiotropy analyses. Among 158,229 participants, PD risk rose with HL severity especially in elder and males, and hearing aids significantly reduced PD risk in males.

Inner Helmholtz layer control through co-solvent strategies for high-performance copper hexacyanoferrate//zinc battery.

Copper hexacyanoferrate (CuHCF) demonstrates high working voltage, convenient synthesis methods, and economic benefits. However, capacity decay of CuHCF//Zn full cells is usually observed in aqueous electrolytes due to the dissolution of Cu and Fe, as indicated by the irreversible insertion of Zn ions and the consequent formation of ZnCuHCF. To address these challenges, a cathode-oriented electrolyte engineering design employing a methyl acetate (MA) co-solvent with zinc triflate (Zn(OTf)) salt electrolyte is implemented.

Broad Evidence Triangulation Should Be Established for a Valid and Robust Causal Relation Between Air Pollution and Health Outcome.

This letter aims to provide valuable insights into broader evidence triangulation (i.e., a well-designed primary association analysis followed by elaborate approaches to control residual confounding effects from various design and modeling perspectives) for clarifying the association between air pollutants and health outcomes.

Adsorption behaviour and mechanism of natural citric acid modified MOF-808 for Cr(III) and Cr(III)-EDTA in water and site energy analysis.

Industrial wastewater often contains potentially toxic metals and it's chelates, posing serious threats to human health and aquatic ecosystems, and adsorption is frequently used for the minimization of potentially toxic metals from water. In this study, citric acid modified MOF-808 (MOF-808-CA) was prepared by using citric acid to modify MOF-808 for the removal of Cr(III) and Cr(III)-EDTA from wastewater. MOF-808-CA with the BET surface area of 653.

Low-Cost Intrinsic Flame-Retardant Bio-Based High Performance Polyurethane and its Application in Triboelectric Nanogenerators.

Flammability is a significant challenge in polymer-based electronics. In this regard, triboelectric nanogenerators (TENGs) have enabled a safe means for harvesting mechanical energy for conversion into electrical energy. However, most existing polymers used for TENGs are sourced from petroleum-based raw materials and are highly flammable, which can further accelerate the spread of fire and harm the ecological environment.

Improving the production of BaEV lentivirus by comprehensive optimization.

With the rapid development of the cell and gene therapy industry, there is an increasing demand for lentiviral vectors that can efficiently infect cells of different purposes. BaEV lentiviruses have been shown to efficiently infect hematopoietic stem cells, primary B cells, and NK cells, which traditional VSV-G lentiviruses cannot infect. However, there is a problem of low virus yield in the production of BaEV lentivirus.

Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells.

Thyroid nodules are a common endocrine condition with an increasing incidence over the decades. Data-independent acquisition has been widely utilized in discovery proteomics to identify disease biomarkers and therapeutic targets. To analyze the thyroid disease-related proteome in a high-throughput, reproducible and reliable manner, we introduce thyroid-specific peptide spectral libraries.