Adhesion Characteristics of an Asphalt Binder-Aggregate Interface Based on Molecular Dynamics.

To investigate the adhesion properties of asphalt binder-aggregate interfaces, contact angle tests were performed on base, aged, and SBS# asphalt with limestone and basalt aggregates. A molecular dynamics simulation model was established to analyze interfacial adhesion characteristics. The results indicate good consistency between the experimental and molecular dynamics simulation findings.

Deep-learning analysis of greenspace and metabolic syndrome: A street-view and remote-sensing approach.

Evidence linking greenspace exposure to metabolic syndrome (MetS) remains sparse and inconsistent. This exploratory study evaluate the relationship between green visibility index (GVI) and normalized difference vegetation index (NDVI) with MetS prevalence, and quantifies the potential reduction in MetS burden from increased greenspace exposure. Participants were selected from the baseline survey of the Wuhan Chronic Disease Cohort.

Dietary vitamin E and tocopherol isoform intake and the progression of chronic kidney disease.

Background And Hypothesis: It is unclear whether dietary vitamin E and tocopherol isoform intake is associated with health outcomes in patients with chronic kidney disease (CKD). We hypothesize that different dietary tocopherol isoforms have different health effects in people with CKD. Therefore, we aimed to investigate the association between dietary vitamin E and tocopherol isoforms and risks of CKD progression and all-cause mortality in patients with CKD.

Climate change and air pollution can amplify vulnerability of glucose metabolism: The mediating effects of biological aging.

Climate change and air pollution pose significant global health threats, including impacts on diabetes risk; however, their long-term effects on insulin resistance (IR), a key determinant in diabetes pathophysiology, remain unclear. This study investigated whether exposure to heatwaves, temperature fluctuations, and warm-season ozone (O) contributes to or exacerbates IR and explored the potential mediating role of biological aging. The study enrolled 6901 participants and assessed both traditional and novel IR indicators: estimated glucose disposal rate (eGDR), triglyceride-glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c), metabolic score for IR (METS-IR), TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), waist-to-height ratio (WHtR), TyG-WHtR, and lipid accumulation product (LAP).

Effects of migrant workers' health capital on their returning home intentions: evidence from China.

Background: The health problems and migration problems of China's huge migrant workers are related to the implementation effect of new-type urbanization and rural revitalization strategy. A thorough examination of the effect of migrant workers' health on their returning home intentions and its mechanism is imperative.

Objectives: This study aims to understand the influence of migrant workers' health capital (HC) in their returning home intentions (RHI).

Supramolecular room-temperature flowable lignin (RTFL)/MXene for sustainable coatings.

Thermoelectric coatings with high biomass content, excellent storage stability, and solvent-free curing capabilities are highly desirable yet challenging. In this study, we demonstrate that supramolecular room-temperature flowable lignin (RTFL) was introduced as an effective carrier for the two-dimensional conductive material MXene, facilitating the development of supramolecular sustainable coatings. Lignosulfonic acid (LA) and polymerizable quaternary ammonium salt monomers were successfully utilized to synthesize the RTFL with ultra-low glass transition temperatures (-67--38 °C) using a deep eutectic strategy, with lignin content reaching up to 50 wt% without relying on traditional solvents.

Relationship of Different Sourced Protein Intake, Quantity of Plasma Amino Acid with Chronic Kidney Disease.

Background: The association of protein from different food sources and different plasma amino acids with risk of chronic kidney disease (CKD) is unclear.

Objectives: We aimed to investigate longitudinal relationships of dietary protein intake from different sources and quantity of plasma amino acids with new-onset CKD in the general population.

Methods: Participants (mean age: 56 y) without CKD at baseline were included in the UK Biobank.

Homochiral Dy zero-field single-molecule magnets derived from axial chiral ligands ()/()-octahydro-1,1'-bi-2-naphthyl phosphate.

The construction of homochiral zero-field single-molecule magnets (SMMs), especially with axial chiral ligands, remains a great challenge. Herein the first examples of homochiral Dy(III) Schiff base complexes based on axial chiral ligands ()/()-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthyl phosphate (-HL/-HL), [Dy(-L/-L)(L)(HO)(MeOH)]·2MeOH·CHCl·2MeCN·2HO (-1/-1) [HL = ()-'-(5-fluoro-2-hydroxybenzylidene)pyrazine-2-carbohydrazide], were synthesized at room temperature, which show ferromagnetic coupling and act as zero-field SMMs, with a / value of 61 K at 0 Oe. calculations were used to explain their magnetic interaction and magnetic relaxation properties.

Plasma proteomics for risk prediction and identification of novel drug targets in systemic lupus erythematosus.

Objectives: The relationship between proteomic profiles and incident systemic lupus erythematosus (SLE) remains unclear. We aimed to identify candidate plasma proteins for SLE risk in women, discover potential treatment targets for SLE, and develop and validate a protein-based prediction model for SLE risk.

Methods: 28 220 women from the UK Biobank were randomly split into training (70%) and testing (30%) sets.

U-Shaped Association Between Dietary Copper Intake and New-Onset Chronic Kidney Disease: A 30-Year Follow-Up Study From Young Adulthood to Midlife.

Scope: The relationship of dietary copper intake with new-onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association of dietary copper intake with new-onset CKD in a 30-year follow-up study from young adulthood to midlife.

Methods And Results: A total of 4038 U.

Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China.

Background: Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown.

Methods And Results: An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.

Holocellulose nanofibrils biomimetic entrapment of liquid metal enable ultrastrong, tough, and lower-voltage-driven paper device.

Integrating liquid metal (LM) with wood fibers for flexible paper electronics is intriguing yet extremely challenging due to poor mechanical performance. Here, we disclose a hemicellulose trapping strategy to achieve exceptional ultrastrong and tough LM-based paper electronics. Holocellulose nanofibrils (HCNFs) with hemicellulose retention of approximately 20 % are found to effectively entrap nanoscale LM within the fibril network, analogous to spider silk capturing small water droplets.

Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study.

Anemia in women of reproductive age (WRA) presents a pressing global public health issue, particularly in low- and middle-income countries (LMICs). Yet, the potential impact of ozone (O) exposure on anemia remains uncertain. The study included 1,467,887 eligible women from 83 surveys of 45 LMICs between 2004 to 2020.

The Association Between Ambient Particulate Matter Exposure and Anemia in HIV/AIDS Patients.

Background: Anemia is common among HIV/AIDS patients, impacting prognosis. Particulate matter (PM) exposure is an understudied, potentially modifiable risk factor in this group.

Methods: We gathered 36,266 hemoglobin (Hb) measurements from 6808 HIV/AIDS patients from the HIV/AIDS Comprehensive Response Information Management System from 1 January 2004 to 31 December 2021.

Association of Social Isolation and Plasma Metabolites With the Risk of Venous Thromboembolism.

Background: To explore the association of social isolation with venous thromboembolism (VTE) risk and the mediating role of metabolomics on this association.

Methods: Overall, 236 026 participants free of VTE and with complete metabolomics data at baseline from the UK Biobank were included. Social isolation was constructed based on the frequency of friend/family visits, weekly group activities, and living alone.

Self-Healing 2D Anion-Organic Frameworks for Low-Temperature Water Release.

Molecular frameworks have recently shown a great potential in atmospheric water harvesting, in which the water release at low temperatures is challenging. Anion-organic frameworks based on anion-coordination chemistry are presented herein to meet this challenge. These frameworks are prepared as tubular single crystals in pure water from the in situ protonation and crystallization of pyridine-terminated triphenylamine derivatives with hydrochloric or hydrobromic acid.

Large-Scale Plasma Proteomics Profiles for Predicting Ischemic Stroke Risk in the General Population.

Background: We aimed to develop and validate a protein risk score for ischemic stroke (IS) risk prediction and to compare its predictive capability with IS clinical risk factors and IS polygenic risk score.

Methods: The prospective cohort study included 53 029 participants from UKB-PPP (UK Biobank Pharmaceutical Proteomics Project). IS protein risk score was calculated as the weighted sum of proteins selected by the least absolute shrinkage and selection operator regression.

Relationship of Serum 25-Hydroxyvitamin D Concentrations, Diabetes, Vitamin D Receptor Gene Polymorphisms and Incident Venous Thromboembolism.

Aims: The association between vitamin D and the risk of venous thromboembolism (VTE) remains inconclusive. We aimed to explore the association of serum 25-hydroxyvitamin D (25OHD) with incident VTE among participants with and without diabetes, and examine the modifying effect of genetic susceptibility of VTE and vitamin D receptor (VDR) gene polymorphisms on this association.

Materials And Methods: A total of 378,082 participants free of VTE at baseline from the UK Biobank were included.

Clinical biomarker-based biological ageing and the risk of adverse outcomes in patients with chronic kidney disease.

Objective: Patients with chronic kidney disease (CKD) show features of premature ageing. We aimed to evaluate the association between biological ageing and adverse outcomes, including end-stage kidney disease (ESKD), cardiovascular diseases (CVD) and all-cause mortality, in patients with CKD.

Methods: 23 435 participants with CKD and free of related adverse outcomes at baseline from the UK Biobank were included.

Comparative study of gut microbiota and metabolite variations between severe and mild acute pancreatitis patients at different stages.

Acute pancreatitis (AP) is influenced by interactions between gut microbiota and metabolic products, though the mechanisms remain unclear. This study investigates variations in gut microbiota and metabolites between severe (SAP) and mild acute pancreatitis (MAP) patients to assess their impact on disease progression. Using a cross-sectional cohort design, gut microbiota and metabolite profiles were compared in SAP and MAP patients over two weeks post-diagnosis.

Coffee consumption with different additives and types, genetic variation in caffeine metabolism and new-onset acute kidney injury.

We aimed to evaluate the association of coffee consumption with different additives, including milk and/or sweetener (sugar and/or artificial sweetener), and different coffee types, with new-onset acute kidney injury (AKI), and examine the modifying effects of genetic variation in caffeine metabolism. 194 324 participants without AKI at baseline in the UK Biobank were included. The study outcome was new-onset AKI.

A Polysocial Approach in Exploring Racial and Ethnic Differences in Dementia and Cognitive Decline Among U.S. Older Adults: Health and Retirement Study.

Background And Objectives: The racial or ethnic disparity in the burden of dementia exists among older adults in the United States, whereas gaps remain in understanding the synergic effect of multiple social determinants of health on diminishing this disparity. We aim to build a polysocial score for dementia and investigate the racial or ethnic difference in dementia risk among older persons with different polysocial score categories.

Research Design And Methods: In this prospective cohort study, we utilized longitudinal data from the Health and Retirement Study in the United States recruiting 6 945 participants aged ≥65 years who had data on 24 social determinants of health in 2006/2008.